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EGFR — PTK2B
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
EGFR
—
PTK2B
(physical association, affinity chromatography technology)
Ivankovic-Dikic et al., Nat Cell Biol 2000*
-
IRef Biogrid Interaction:
EGFR
—
PTK2B
(physical association, affinity chromatography technology)
Keely et al., J Biol Chem 2000*
-
IRef Hprd Interaction:
EGFR
—
PTK2B
(in vivo)
Keely et al., J Biol Chem 2000*
-
IRef Intact Interaction:
Complex of 23 proteins
(association, anti bait coimmunoprecipitation)
Thelemann et al., Mol Cell Proteomics 2005
-
IRef Intact Interaction:
Complex of 70 proteins
(association, anti bait coimmunoprecipitation)
Thelemann et al., Mol Cell Proteomics 2005
-
IRef Ophid Interaction:
EGFR
—
PTK2B
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
EGFR
—
PTK2B
(aggregation, confirmational text mining)
Keely et al., J Biol Chem 2000*
-
STRING interaction:
EGFR
—
PTK2B
(interaction, mapped from bind reactome kegg_pathways)
-
STRING interaction:
PTK2B
—
EGFR
(interaction, mapped from grid kegg_pathways mint intact)
Text-mined interactions from Literome
Ohtsu et al., Arterioscler Thromb Vasc Biol 2005
(Cardiovascular Diseases) :
We have further demonstrated that the Rho/ROCK activation by Ang II requires protein kinase C-delta (PKCdelta) and
proline-rich tyrosine kinase 2 (PYK2) activation, but not
epidermal growth factor receptor transactivation
Park et al., Cell Signal 2006
:
Using specific pharmacological inhibitors, we found that the tyrosine phosphorylation of
RAFTK/Pyk2 was intracellular Ca2+ dependent, but not
EGFR dependent , during LPA stimulation of these cells