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IL12B — KLRB1
Text-mined interactions from Literome
Poggi et al., J Immunol 1999
(Multiple Sclerosis) :
IL-12 mediated
NKRP1A up-regulation and consequent enhancement of endothelial transmigration of V delta 2+ TCR gamma delta+ T lymphocytes from healthy donors and multiple sclerosis patients ... No
up-regulation of
NKRP1A by
IL-12 was noted on V delta 1+ clones ... We conclude that the expression of
NKRP1A on V delta 2+ cells is associated with increased ability to migrate across the vascular endothelium and that this phenomenon may be
regulated by
IL-12 present in the microenvironment
Annunziato et al., Curr Opin HIV AIDS 2010
:
Human Th17 cells express
CD161 and exclusively originate from CD161 precursors present in umbilical cord blood and newborn thymus in
response to the combined activity of IL-1beta and
IL-23
Shen et al., PloS one 2013
:
Variable expression of
CD161 , IL-23R and RORC
affects IL-23 responsiveness and contributes to the inter-individual susceptibility to IL-23 mediated defenses and inflammatory processes
Poggi et al., Eur J Immunol 1998
:
IL-12 induced
up-regulation of
NKRP1A expression in human NK cells and consequent NKRP1A mediated down-regulation of NK cell activation ...
IL-12 , in contrast to IL-2, strongly
up-regulated the expression of the
NKRP1A lectin molecule on human NK cells ... The
IL-12 induced
NKRP1A expression was time and dose dependent, reaching a maximum by 7 days of culture in the presence of 2 ng/ml IL-12 and it was inhibited by the addition of anti-IL-12 monoclonal antibody ... The
IL-12 dependent
NKRP1A up-regulation was abrogated by the incubation of NK cells with actinomycin D, thus suggesting that IL-12 induces de novo transcription of NKRP1A mRNA
Azzoni et al., J Immunol 1998
:
Differential transcriptional
regulation of
CD161 and a novel gene, 197/15a, by IL-2, IL-15, and
IL-12 in NK and T cells ...
CD161 transcription, mRNA accumulation, and surface expression are
increased by
IL-12