◀ Back to RELA
RELA — S100B
Text-mined interactions from Literome
Lam et al., Neurobiol Aging 2001
(Alzheimer Disease) :
Mechanism of glial
activation by
S100B : involvement of the transcription factor
NFkappaB
Bianchi et al., Neurobiol Aging 2010
(Encephalitis...) :
We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 )
S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression
requires the concurrent activation of
NF-kappaB and AP-1
Tubaro et al., J Cell Physiol 2010
:
Conversely, silencing
S100B expression in myoblast cell lines by RNA interference
resulted in reduced
NF-kappaB activity and enhanced MyoD, myogenin and MyHC expression and myotube formation