Zhu et al., Curr Biol 2007
(Glaucoma) :
Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP ... Optineurin competitively antagonized NEMO 's binding to polyUb RIP, and its overexpression inhibited TNFalpha induced NF-kappaB activation ... This competition occurs at physiologic protein levels because microRNA silencing of optineurin resulted in markedly enhanced TNFalpha induced NF-kappaB activity
Sudhakar et al., PloS one 2009
:
NF-kappaB mediates tumor necrosis factor alpha induced expression of optineurin , a negative regulator of NF-kappaB ... Blocking of NF-kappaB activation resulted in inhibition of TNFalpha induced optineurin gene expression ... Overexpressed optineurin partly inhibited TNFalpha induced NF-kappaB activation in Hela cells ... Downregulation of optineurin by shRNA resulted in an increase in TNFalpha induced as well as basal NF-kappaB activity