Gene interactions and pathways from curated databases and text-mining

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MPO — RELA

Text-mined interactions from Literome

Hassoun et al., Am J Physiol Gastrointest Liver Physiol 2002 (Intestinal Obstruction...) : Rats subjected to I/R exhibited markedly depressed intestinal transit, histological evidence of severe injury to the ileum, increased myeloperoxidase activity in ileal cytoplasmic extracts, and biphasic activation of NF-kappaB in ileal nuclear extracts
Nys et al., Clin Sci (Lond) 2002 (Bronchopneumonia...) : NF-kappaB activation by MPO was also demonstrated
Yang et al., Inflamm Res 2005 (Disease Progression...) : We demonstrated that intravenous administration of endotoxin could provoke significant lung injury, which was characterized by increase of MPO activity and wet/dry weight ratio, TNF-alpha and IL-6 expression and NF-kappa B activation
Nys et al., Vascul Pharmacol 2005 (Lung Diseases) : Nitric oxide related products and myeloperoxidase in bronchoalveolar lavage fluids from patients with ALI activate NF-kappa B in alveolar cells and monocytes ... Furthermore, in vitro studies confirmed that NO* derived species ( peroxynitrite and nitrites ) and the neutrophil enzyme myeloperoxidase by themselves increased the activation of NF-kappaB , thereby arguing for an in vivo pathogenetic role of NO* related products and neutrophil enzymes to human ALI
Lin et al., J Am Soc Nephrol 2008 (Acute Kidney Injury...) : Measures of inflammation ( number of infiltrating neutrophils, myeloperoxidase activity, and induction of IL-6 and P-selectin ) and activation of NF-kappaB were lower in GC-G ( -/- ) mice compared with wild-type mice
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta, and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Di Paola et al., Intensive Care Med 2009 (Hypertension...) : Administration of glycyrrhizin, significantly reduced the ( a ) fall of mean arterial blood pressure, ( b ) mortality rate, ( c ) myeloperoxidase (MPO) activity, ( d ) production of pro-inflammatory cytokines [tumor necrosis factor-alpha ( TNF-alpha ) and interleukin-1beta (IL-1beta) ], ( e ) histological evidence of gut injury, ( f ) immunoreactivity of nitrotyrosine, ( g ) poly ADP-ribose ( PAR ) formation, ( h ) the expression of ICAM-1 and P-selectin, ( i ) activation of nuclear factor-kappaB (NF-kappaB) and ( j ) signal transducer and activator transcription-3 ( STAT-3 ) induced by splanchnic artery occlusion-reperfusion shock
Chen et al., J Biomed Sci 2010 (Burns) : Commensal depletion decreased TLR4 expression as well as NF-kappaB activation of intestine, myeloperoxidase (MPO) activity as well as TNFalpha expression of lung, and bacterial killing activity of peritoneal cells