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APP — MAPK8IP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MAPK8IP1 — APP Scheinfeld et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: MAPK8IP1 — APP (fluorescent resonance energy transfer) Scheinfeld et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: MAPK8IP1 — APP (coimmunoprecipitation) Scheinfeld et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: MAPK8IP1 — APP (affinity chromatography technology) Scheinfeld et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: MAPK8IP1 — APP (two hybrid) Scheinfeld et al., J Biol Chem 2002*
• IRef Biogrid Interaction: MAPK8IP1 — APP (direct interaction, two hybrid) Kajiwara et al., Molecular neurodegeneration 2010
• IRef Biogrid Interaction: MAPK8IP1 — APP (direct interaction, pull down) Scheinfeld et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MAPK8IP1 — APP (direct interaction, enzymatic study) Scheinfeld et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MAPK8IP1 — APP (physical association, affinity chromatography technology) Muresan et al., J Cell Biol 2005*
• IRef Hprd Interaction: Complex of APP-KLC1-APP-MAPK8IP1-MAPK8IP1-KLC1-APP-MAPK8IP1-KLC1 (in vivo) Matsuda et al., J Biol Chem 2003*
• IRef Hprd Interaction: APP — MAPK8IP1 (two hybrid) Matsuda et al., J Neurosci 2001*, Scheinfeld et al., J Biol Chem 2002*, Matsuda et al., J Biol Chem 2003*
• IRef Hprd Interaction: APP — MAPK8IP1 (in vitro) Matsuda et al., J Neurosci 2001*, Scheinfeld et al., J Biol Chem 2002*, Matsuda et al., J Biol Chem 2003*
• IRef Hprd Interaction: APP — MAPK8IP1 (in vivo) Matsuda et al., J Neurosci 2001*, Scheinfeld et al., J Biol Chem 2002*, Matsuda et al., J Biol Chem 2003*
• IRef Innatedb Interaction: Complex of MAP3K11-MAPK8IP1-APP (unknown, -) Scheinfeld et al., J Biol Chem 2003*
• IRef Innatedb Interaction: Complex of APP-MAPK8IP1-MAPK8 (unknown, -) Scheinfeld et al., J Biol Chem 2003*
• IRef Innatedb Interaction: MAPK8IP1 — APP (unknown, -) Scheinfeld et al., J Biol Chem 2003*
• IRef Intact Interaction: MAPK8IP1 — APP (direct interaction, fluorescent resonance energy transfer) Scheinfeld et al., J Biol Chem 2002*
• IRef Intact Interaction: MAPK8IP1 — APP (physical association, pull down) Scheinfeld et al., J Biol Chem 2002*
• IRef Intact Interaction: MAPK8IP1 — APP (physical association, two hybrid) Scheinfeld et al., J Biol Chem 2002*
• IRef Intact Interaction: MAPK8IP1 — APP (physical association, anti tag coimmunoprecipitation) Scheinfeld et al., J Biol Chem 2002*
• IRef Ophid Interaction: MAPK8IP1 — APP (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MAPK8IP1 — APP (aggregation, confirmational text mining) Scheinfeld et al., J Biol Chem 2002*

Text-mined interactions from Literome

Matsuda et al., J Neurosci 2001 (Alzheimer Disease) : The APP amino acids Tyr ( 682 ), Asn ( 684 ), and Tyr ( 687 ) in the G ( 681 ) YENPTY ( 687 ) region were all essential for APP/JIP-1b interaction, but neither Tyr ( 653 ) nor Thr ( 668 ) was necessary ... Moreover, human JNK1beta1 formed a complex with APP in a JIP-1b dependent manner
Taru et al., J Biol Chem 2002 (Alzheimer Disease) : Overexpression of JIP1b slightly enhances the JNK dependent threonine phosphorylation of APP in cultured cells, but that of JIP2 suppresses it
Taru et al., J Biol Chem 2002 : The expression of JIP1b stabilizes immature APP and suppresses the production of a secreted large extracellular amino-terminal domain of APP, the generation of a cleaved intracellular carboxyl-terminal fragment of APP, and the secretion of beta-amyloid 40 and 42
Inomata et al., J Biol Chem 2003 (MAP Kinase Signaling System) : In this study, we isolated JIP-1b, a JNK signaling scaffold protein, as a binding protein of APP, and analyzed the roles of JIP-1b in APP phosphorylation by JNK and the association of kinesin light chain 1 with APP ... JIP-1b also enhanced the association of kinesin light chain 1 with APP
Muresan et al., J Cell Biol 2005 : These results indicate that the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP