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CD2 — TNF

Text-mined interactions from Literome

Meinl et al., J Immunol 2000 (Severe Combined Immunodeficiency) : CD2 induced proliferation as well as production of TNF-alpha and IFN-gamma was abrogated in ZAP-70-deficient T cells, whereas PMA plus ionomycin induced normal activation of these cells
Eaves-Pyles et al., J Immunol 2001 : ND1-2/ECH/CD2-1 also induced high levels of TNF-alpha ( 900 pg/ml ) in human monocytes comparable to native SD flagellin ( 991.5 pg/ml ) and 6HIS flag ( 987 pg/ml )
Lorré et al., Eur Cytokine Netw 1992 : rIL-1 beta supported anti-CD2 induced TNF-alpha production indirectly through an IL-2 dependent pathway ... We conclude that CD3 or CD2 triggering are not sufficient for TNF-alpha production by T cells, but that the latter is dependent ( apparently at the transcriptional level ) on the interaction of IL-2 with its functionally active cell surface receptors
Robinet et al., J Immunol 1990 : TNF did not affect the expression of LFA1, CD2 , CD4, and CD8, molecules that are associated with CTL-target interactions, on responder cells
Chavin et al., Ann Surg 1993 : Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor , and transforming growth factor-beta production
Putz et al., Scand J Immunol 1996 : Mannose-6-phosphate, an inhibitor of L-selectin binding, blocked CD2 induced TNF production whereas other ligands for L-selectin ( the monomeric monoclonal antibody to L-selectin, DREG-200 ; inositol hexaphosphoric acid ; heparin ) amplified CD2 induced secretion of TNF