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CDH5 — RAC3
Text-mined interactions from Literome
Kovacs et al., J Biol Chem 2002
:
We report that homophilic
cadherin ligation recruits Rac to nascent adhesive contacts and specifically
stimulates Rac signaling
Goodwin et al., J Biol Chem 2003
:
Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase : direct evidence of a role for
cadherin activated
Rac signaling in adhesion and contact formation ... These data provide direct evidence for a role of
cadherin activated
Rac signaling in contact formation and adhesive stabilization
Fukuyama et al., Oncogene 2006
:
Activation of
Rac by
cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway ... However, it has not fully been understood how
cadherin induces the activation of
Rac
Kraemer et al., Am J Physiol Cell Physiol 2007
:
To pursue upstream elements of the Rac1 signaling pathway, we focused on the potential contribution of Tiam1 to
cadherin activated
Rac signaling
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2008
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Molecular inhibition of paxillin also attenuated OxPAPC induced enhancement of adherens junctions critical for the EC barrier-protective response, accumulation of
vascular endothelial cadherin in the membrane fractions, and decreased
activation of
Rac and its effector p21 activated kinase ( PAK1 )
Birukova et al., J Cell Physiol 2012
:
In contrast, disruption of
VE-cadherin extracellular trans-interactions
suppressed iloprost activated
Rac signaling and attenuated EC barrier enhancement and cytoskeletal remodeling