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CDH1 — RAC3

Text-mined interactions from Literome

Kovacs et al., J Biol Chem 2002 : In this study, we used a functional cadherin ligand ( hE/Fc ) to directly test whether E-cadherin ligation regulates phosphatidylinositol 3-kinase ( PI 3-kinase ) and Rac signaling ... We report that homophilic cadherin ligation recruits Rac to nascent adhesive contacts and specifically stimulates Rac signaling
Goodwin et al., J Biol Chem 2003 : Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase : direct evidence of a role for cadherin activated Rac signaling in adhesion and contact formation ... These data provide direct evidence for a role of cadherin activated Rac signaling in contact formation and adhesive stabilization
Honda et al., Genes Cells 2003 : Cdc42 or Rac was not essential for the association of nectin-1 and E-cadherin to form AJs
Hoshino et al., Mol Biol Cell 2004 : A novel role of nectins in inhibition of the E-cadherin induced activation of Rac and formation of cell-cell adherens junctions ... Moreover, we found here that the nectins, which did not trans-interact with other nectins ( non-trans interacting nectins ), inhibited the E-cadherin induced activation of Rac and reduced the velocity of the formation of the E-cadherin based cell-cell AJs ... These results indicate a novel role of nectins in regulation of the E-cadherin induced activation of Rac and formation of cell-cell AJs
Fukuyama et al., Oncogene 2006 : Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway ... However, it has not fully been understood how cadherin induces the activation of Rac
Kraemer et al., Am J Physiol Cell Physiol 2007 : To pursue upstream elements of the Rac1 signaling pathway, we focused on the potential contribution of Tiam1 to cadherin activated Rac signaling
Sakisaka et al., Methods Mol Biol 2008 : The endocytosis of trans interacting E-cadherin was inhibited by Rac and Cdc42 small G proteins, which were activated by trans interacting E-cadherin