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BMP6 — MAPK4
Text-mined interactions from Literome
Viñals et al., FEBS Lett 2002
:
In contrast,
BMP-2 had no effect on p42/p44
MAPK ( Erks ) stimulation
Darby et al., J Pathol 2008
(Neoplasm Invasiveness...) :
BMP-6 stimulation also
led to an increase in phosphorylation levels of
MAPK proteins
Takahashi et al., J Endocrinol 2008
:
Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen induced proliferation of breast cancer cells by
suppressing p38
mitogen activated protein kinase activation ... Estradiol rapidly activated
MAPK phosphorylation including extracellular signal regulated kinase 1/2, p38, and stress activated protein kinase/c-Jun NH2-terminal kinase pathways and
BMP6 , BMP7, and activin preferentially
inhibited estradiol induced p38 phosphorylation
Leong et al., PloS one 2009
(Osteoporosis) :
These results indicate that protein palmitoylation plays an important role in
BMP induced
MAPK activation, osterix expression, and osteoblast differentiation
Ge et al., J Bone Miner Res 2012
(MAP Kinase Signaling System) :
Significantly, in the presence of AA,
BMP2/7 synergistically stimulated RUNX2 S319 phosphorylation and transcriptional activity without affecting total RUNX2 and this response was totally
dependent on
ERK/MAPK activity
Ebeling et al., Reprod Fertil Dev 2011
:
Furthermore,
BMP-6 did not
affect the activity of the
mitogen activated protein kinase
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells, Tak1 is not only required for TGF-ß- and
bone morphogenetic protein induced p38
Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads