◀ Back to LEP
LEP — PRKAA2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Andersson et al., J Biol Chem 2004
:
The finding that
leptin and adiponectin
activate AMPK to alter metabolic pathways in muscle and liver provides direct evidence for this role in peripheral tissues
Leclerc et al., Am J Physiol Endocrinol Metab 2004
:
Here, we explore whether 1 ) glucose, metformin, or
leptin regulates
AMPK activity in isolated islets from rodent and human and 2 ) whether changes in AMPK activity modulate insulin secretion from human islets
Solinas et al., FEBS Lett 2004
:
Our results suggest that the direct effect of
leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle
requires both PI3K and
AMPK signaling
Yu et al., Diabetologia 2004
(Diabetes Mellitus...) :
Leptin has been shown to
activate AMP activated protein kinase (AMPK) , an enzyme that regulates the activities of key enzymes of lipid synthesis and metabolism
Rossmeisl et al., Int J Obes Relat Metab Disord 2004
(Choristoma...) :
Moreover, it has been shown that
AMPK in adipocytes can be
activated by adipocyte derived hormones
leptin and adiponectin, and also by insulin-sensitizes thiazolidinediones
Carling et al., Biochimie 2005
:
In the hypothalamus,
AMPK is
inhibited by
leptin and insulin, hormones which suppress feeding, whilst ghrelin, a hormone that increases food intake, activates AMPK
Brabant et al., FASEB J 2005
(Insulin Resistance...) :
AMPKalpha protein levels as well as basal and
leptin stimulated total and alpha-specific
AMPK activity were comparable in both groups
Steinberg et al., Endocrinology 2006
(Obesity) :
Both
leptin and CNTF
reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the ARC and PVN of control fed mice
Daval et al., J Physiol 2006
:
Leptin and adiponectin as well as hypoglycaemic drugs are
activators of adipose tissue
AMPK
Uotani et al., Biochem Biophys Res Commun 2006
:
Here, we report that the
leptin induced phosphorylation of
AMPK was detected in Huh7 cells expressing long form leptin receptor ( OBRb ) as well as short form leptin receptor ( OBRa ) ... We also show that Huh7 cells expressing OBRb and SOCS3 ( inhibitor of JAK2 ) resulted in a marked reduction of
AMPK activation in
response to
leptin ... These findings suggest that the activation of JAK2, but not STAT3, may play a critical role in
leptin induced
AMPK activation in Huh7 cells
Canabal et al., Am J Physiol Regul Integr Comp Physiol 2007
:
The effects of glucose and
leptin were
mediated by suppression of
AMP activated protein kinase (AMPK)
Janovská et al., Mol Cell Endocrinol 2008
(Body Weight...) :
AMPK activation by
leptin occurred independently of energy related metabolites
Minokoshi et al., Nutrition 2008
(Body Weight) :
Leptin inhibits
AMPK activity in the arcuate and paraventricular hypothalamus, and its inhibition is necessary for the anorexic effect of leptin
Murphy et al., Am J Physiol Cell Physiol 2009
(Synaptic Transmission) :
However, after a fast, decreased
leptin and glucose
activate AMPK in NPY-GI neurons
Procopio et al., Endocrinology 2009
:
Preincubation of leptin with human recombinant CRP impaired
leptin induced
AMPK activation , eNOS-Ser ( 1177 ) phosphorylation, eNOS activity, and intracellular cGMP accumulation
Tang et al., Endocrinology 2010
:
In summary, curcumin eliminated stimulatory
effects of
leptin on HSC activation and increased
AMPK activity, leading to inducing expression of genes relevant to lipid accumulation and elevating the level of intracellular lipids
Borges et al., Am J Physiol Endocrinol Metab 2011
(Body Weight...) :
However,
leptin had no effects on 2-AG, p-STAT3, or
p-AMPK in the 1LPS and 6LPS groups
Greco et al., Biochem Biophys Res Commun 2011
(Alzheimer Disease) :
Leptin directly
activated neuronal
AMPK and SIRT in cell lines
Moon et al., Diabetologia 2012
:
Leptin and amylin in combination
activated STAT3,
AMP activated protein kinase (AMPK) , extracellular signal regulated kinase ( ERK ) 1/2 and Akt signalling pathways in an additive manner, effects that were abolished under endoplasmic reticulum ( ER ) stress
Dagon et al., Cell Metab 2012
(Body Weight) :
Serine ( 491 ) phosphorylation is necessary for
leptin 's
effects on hypothalamic
a2AMPK activity, neuropeptide expression, food intake, and body weight
Stark et al., Mol Cell Endocrinol 2013
:
These mechanisms include ( 1 ) ghrelin stimulation of AMPK in NPY/AgRP in the arcuate nucleus ( 2 ) ghrelin stimulation of AMPK in the ventromedial hypothalamic nucleus, ( 3 ) a novel ghrelin stimulated AMPK dependent presynaptic mechanism that sustains AgRP neuron firing via a local synaptic memory system, ( 4 ) adiponectin
stimulation of hypothalamic
AMPK and ( 5 ) hypothalamic AMPK control of energy expenditure by thyroid hormone or
leptin
Miyamoto et al., J Biol Chem 2012
(Fatty Liver...) :
Hepatic AMPK activities were decreased in fatty liver from lipodystrophic mice, and
leptin activated the hepatic
AMPK via the a-adrenergic effect ... Although
leptin is shown to
activate 5'-AMP activated protein kinase (AMPK) in the skeletal muscle, the effect of leptin in the liver is still unclear ... We investigated the
effect of
leptin on hepatic
AMPK and its pathophysiological relevance in A-ZIP/F-1 mice, a model of generalized lipodystrophy ... Here, we demonstrated that
leptin activates hepatic
AMPK through the central nervous system and a-adrenergic sympathetic nerves
Moon et al., Diabetologia 2013
:
Amylin induced downregulation of hippocampal neurogenesis is attenuated by
leptin in a
STAT3/AMPK/ERK dependent manner in mice
Fuentes et al., Gen Comp Endocrinol 2013
:
Leptin increased during fasting concomitantly with
AMPK activation, which was inversely correlated with TOR activation
Park et al., Proc Natl Acad Sci U S A 2013
:
We discovered that the molecular mechanism of
leptin induced
AMPK activation involves canonical transient receptor potential 4 and calcium/calmodulin dependent protein kinase kinase ß. AMPK activation was dependent on both leptin and glucose concentrations, so at optimal concentrations of leptin, AMPK was activated sufficiently to induce KATP channel trafficking and hyperpolarization of pancreatic ß-cells in a physiological range of fasting glucose levels