Gene interactions and pathways from curated databases and text-mining

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LEP — MSH5

Text-mined interactions from Literome

Forbes et al., Proc Natl Acad Sci U S A 2001 (Weight Gain...) : Here we show that leptin administered to leptin-deficient ( ob/ob ) mice results in a large increase in peripheral MSH levels ; further, peripheral administration of an MSH analogue results in a reversal of their abnormally low metabolic rate, in an acceleration of weight loss during a fast, in partial restoration of thermoregulation in a cold challenge, and in inducing serum free fatty acid levels
Watanobe et al., J Neurosci 2002 : Leptin stimulated the release of alpha-MSH in the fasted but not fed rats
Hoggard et al., J Mol Endocrinol 2004 (Obesity) : Leptin administered to ob/ob mice in turn increases the release of alpha-MSH into the circulation, suggesting a possible feedback loop between the site of alpha-MSH release and the release of leptin from the adipose tissue
Breen et al., Brain Res 2005 : Here we have examined the effects of fasting, leptin , and insulin on the release of AGRP and the POMC derived peptide gamma ( 3 ) -MSH from the perifused rat hypothalamus in vitro
Mastronardi et al., Neuroimmunomodulation 2005 (Bacterial Infections...) : Our results suggest that alpha-MSH increased leptin release without altering its synthesis, but when LPS increased release and synthesis of leptin, alpha-MSH, although further increasing release, blocked the enhanced synthesis of leptin elicited by LPS
Lectez et al., Endocrinology 2009 : Finally, 26RFa antagonized the effects of leptin on NPY expression and release, POMC expression and alpha-MSH release, and food intake