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MAPK15 — SOS1

Text-mined interactions from Literome

Weng et al., Hum Mol Genet 2001 (Breast Neoplasms) : PTEN inhibits insulin stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
Shindo et al., J Gastroenterol 2006 (Wounds and Injuries) : ( 1 ) SOS activated IkappaB-alpha, but it did not activate ERK1/2 MAPK
Tartaglia et al., Molecular syndromology 2010 : SHP2 ( encoded by PTPN11 ), SOS1 , BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations ... SHP2 ( encoded by PTPN11 ), SOS1 , BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Corbalan-Garcia et al., Mol Cell Biol 1996 : Previous studies have demonstrated that growth factor induced Sos phosphorylation occurs at the C-terminal region of the protein and is mediated , in part, by mitogen activated protein ( MAP ) kinase
Lopez-Ilasaca et al., Science 1997 : The tyrosine kinase class of receptors induces mitogen activated protein kinase ( MAPK ) activation through the sequential interaction of the signaling proteins Grb2, Sos , Ras, Raf, and MEK
Nimnual et al., Science 1998 : Ras mediated activation of DH-PH-Sos did not require activation of mitogen activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase