◀ Back to PIK3CA
BTK — PIK3CA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lindvall et al., Biochem Biophys Res Commun 2002
:
In addition, we have investigated the
involvement of
PI 3-K in the MAPKs and ERK and JNK phosphorylation, in the presence or absence of
Btk
Barbee et al., Int Immunol 2006
(Calcium Signaling) :
Since
PI3K can
affect activation of
Btk , which in turn potentiates calcium fluxes, during B cell development, our results suggest that PI3K could play a role in the regulation of Itk kinases in T cells, and that both cell types share a common signaling network to modulate calcium responses downstream of their antigen receptor
Kuehn et al., J Immunol 2008
(Calcium Signaling...) :
The FcepsilonRI dependent
activation of
Btk and eicosanoid and ROS generation in bone marrow derived mast cells and human mast cells were similarly blocked by the
PI3K inhibitors, Wortmannin and LY294002, indicating that Btk regulated eicosanoid and ROS production occurs downstream of PI3K
Singhal et al., J Biol Chem 2011
:
Notably,
Btk activation is
necessary for HGF induced association of c-Src and
PI3K with c-MET