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EGFR — LEP

Text-mined interactions from Literome

Shida et al., Cancer Res 2005 (MAP Kinase Signaling System...) : We also revealed that tyrosine phosphorylation of EGFR induced by leptin was significantly attenuated by two inhibitors, an EGFR tyrosine kinase inhibitor, AG1478, and a broad-spectrum matrix metalloproteinase inhibitor, GM6001 ... This indicates that the pathway of EGFR transactivation induced by leptin is dependent on proteolytically released EGFR ligands
Beales et al., Mol Cell Endocrinol 2007 (Adenocarcinoma...) : Leptin synergistically enhanced acid stimulated EGFR and ERK phosphorylation but did not further increase JNK or p38 MAP kinase phosphorylation
Chao et al., Eur J Pharmacol 2007 : Leptin induced significant tyrosine phosphorylation of epidermal growth factor receptor , which was significantly attenuated by two inhibitors, an epidermal growth factor receptor tyrosine kinase inhibitor, AG1478, and a broad-spectrum matrix metalloproteinase inhibitor, GM6001 ... This indicates that the pathway of epidermal growth factor receptor transactivation induced by leptin is dependent on proteolytically released epidermal growth factor receptor ligands
Ogunwobi et al., Br J Biomed Sci 2008 (Adenocarcinoma...) : This study examines the effect of leptin on EGFR signalling in cultured cell lines ... The MMP inhibitors also abolished leptin induced proliferation as well as leptin induced EGFR tyrosine phosphorylation, but did not affect proliferation or EGFR activation induced by TGFalpha
Slomiany et al., J Physiol Pharmacol 2009 : These findings point to the involvement of MMP-9 in the event of leptin induced EGFR transactivation that results in the signaling cascade leading to cPLA(2) activation and up-regulation in PGE ( 2 ) generation, thus providing new insights into the mechanism of oral mucosal protection against ethanol toxicity