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SIRT6 — TP53

Text-mined interactions from Literome

Kanfi et al., FEBS Lett 2008 : In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient dependent regulation of SIRT6
van Leeuwen et al., Adv Cancer Res 2009 (Neoplasms) : Preliminary observations also suggest that sirtuin mediated modulation of p53 can also take place indirectly through changes in cellular processes ( e.g., nucleolar function and p300 activity ) known to affect p53
Lynch et al., PloS one 2010 : Thus, SIRT1 mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing
Van Meter et al., Cell cycle (Georgetown, Tex.) 2011 : This cell death requires the mono-ADP-ribosyltransferase but not the deacetylase activity of SIRT6 and is mediated by the activation of both the p53 and p73 apoptotic signaling cascades in cancer cells by SIRT6
van Leeuwen et al., Mol Cancer Ther 2013 : These results help understand why inhibition of both SirT1 and SirT2 is needed to achieve effective activation of p53 by small-molecule sirtuin inhibitors