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SESN2 — TP53

Pathways - manually collected, often from reviews:

• KEGG p53 signaling pathway: TP53 → SESN1/SESN2/SESN3 (gene expression, expression)

Text-mined interactions from Literome

Donadelli et al., Biochim Biophys Acta 2006 (Adenocarcinoma...) : Conversely, PDTC does not affect P21 ( WAF1/CIP1 ) gene expression in primary fibroblasts, although it is able to activate p53 and the p53 regulated antioxidant SESN2
Solhaug et al., Mutat Res 2012 : AOH induced Sestrin 2 expression was regulated by p53 and could at least partly be inhibited by antioxidants, suggesting a role of ROS in the response
Ben-Sahra et al., Cell Death Differ 2013 : The increase of Sesn2 is independent of p53 but requires the anti-apoptotic pathway, PI3K/Akt