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CXCL10 — TAT
Text-mined interactions from Literome
Kutsch et al., J Virol 2000
(HIV Infections) :
Herein, we demonstrate that HIV-1
Tat ( 72aa ) is a potent
inducer of MCP-1, interleukin-8 (IL-8), and
IP-10 expression in astrocytes ... In contrast,
Tat mediated
IP-10 mRNA induction was suppressed by SB202190 but not by the MEK1/2 inhibitor UO126
D'Aversa et al., J Neurovirol 2004
(AIDS Dementia Complex) :
Tat induced
CXCL10 expression was mediated, to some extent, by activation of the ERK1/2 MAPK pathway, phosphatidylinositol 3-kinase pathway, and the p38 MAPK pathway, whereas CCL5 expression was not mediated by any pathway tested
Dhillon et al., J Neurovirol 2008
(AIDS Dementia Complex) :
Synergistic
induction of
CXCL10 by both
Tat and IFN-gamma was susceptible to inhibition by the MEK1/2 inhibitor U0126 and the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580 ... In addition, JAK/STAT pathway plays a major role in
Tat/gamma mediated
CXCL10 induction in macrophages because pretreatment of stimulated macrophages with JAK inhibitor completely abrogated the synergistic induction of the chemokine
Williams et al., Glia 2010
:
In this study we have demonstrated that HIV-1
Tat increases
CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase
Qu et al., BMC immunology 2012
(Coinfection...) :
HIV-1 Tat and IP-10 activated HCV replication in a time dependent manner, and HIV-1
Tat induced
IP-10 production
Davis et al., Neurochem Int 2013
:
Interferon ( IFN ) ?+HIV-1
Tat induced
CXCL10 expression ( secreted protein and mRNA ) was inhibited by co-treatment with ß-FNA ... Neither the MOR-selective antagonist, D-Phe-Cys-Tyr-D-Trp-Arg-Pen-Thr-NH2 ( CTAP ) nor the nonselective opioid receptor antagonist, naltrexone inhibited IFN?+HIV-1
Tat induced
CXCL10 expression ... Furthermore, co-treatment with excess CTAP or naltrexone did not prevent ß-FNA mediated inhibition of IFN?+HIV-1
Tat induced
CXCL10 expression ... Additionally, we utilized an inhibitor of NF-?B activation ( SN50 ) to demonstrate that IFN?+HIV-1
Tat induced
CXCL10 expression is NF-?B dependent in NHA