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LEP — RHOA

Text-mined interactions from Literome

Zeidan et al., J Pharmacol Exp Ther 2007 (Hypertrophy) : Leptin significantly increased RhoA activity by 163 +/- 20 %, whereas phosphorylation of downstream factors, including LIM kinase 1 and cofilin-2, was increased by 160 +/- 25 and 290 +/- 25 %, respectively ... Our results indicate that the activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Jaffe et al., Int J Cancer 2008 (Colonic Neoplasms...) : A direct and novel dose- and time dependent activation of RhoA , Cdc42 and Rac1 by leptin is demonstrated in these aggressive colon cancer cells ... The Src kinase inhibitor II (SrcKI-II) exerted a positive effect on RhoA activation, inhibited tyrosine phosphorylation of p190RhoGAP and inhibited leptin induced Cdc42 activation and leptin induced lamellopodium formation and cell invasion ... The specific JAK2 inhibitor AG490 exerted a positive effect on Rac1 and Cdc42 activation by leptin and concomitantly inhibited RhoA activation ... These signaling pathways induce the activation of Rac1 and Cdc42, lamellopodium formation and concomitantly enhanced cell invasion, but leptin activation of RhoA is not associated with enhanced cell locomotion and invasion
Jiang et al., Hepatology 2008 : Leptin also induced RhoA activation and translocation to the phagosomes
Zeidan et al., Mol Cell Biochem 2011 : The specific mTOR inhibitor rapamycin ( 10 nM ) attenuated leptin induced RhoA and Rac1 activation ... Our results demonstrate a critical role for PI3K/mTOR/p70 ( S6K ) in leptin induced RhoA activation resulting in cardiomyocyte hypertrophy associated with GATA4 stimulation
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : Rho guanine nucleotide exchange factors ( GEFs ) catalyze the exchange of GDP for GTP resulting in Rho activation and may be the potential upstream factors mediating leptin induced RhoA activation and therefore a potential target for inhibition ... The stimulation of RhoA/ROCK by leptin was associated with significantly increased p115RhoGEF gene and protein expression and exchange activity, all of which were completely prevented by ginseng ... The ability of ginseng to prevent leptin induced activation of RhoA/ROCK was further associated with diminished p38 MAPK activation and nuclear translocation