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CASP8 — TGFB1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CASP8
→
TGFB1
(increases, TGFB1 Activity)
Evidence: We detected cleavage of caspases 2, 3, 7, 8, and 9 into their active subunits. Consistent with the involvement of these enzymes in TGF-beta-mediated apoptosis, the broad spectrum caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(Ome)-flouromethylketone (ZVAD-fmk) blocked TGF-beta-induced apoptosis
Text-mined interactions from Literome
Shima et al., Hepatology 1999
(Carcinoma, Hepatocellular...) :
Activation of
caspase-8 in
transforming growth factor-beta induced apoptosis of human hepatoma cells
Hishikawa et al., Eur J Pharmacol 1999
:
Moreover,
TGF-beta(1) activated
caspase 3 in HASC, and the CTGF antisense oligonucleotide reduced this activation
Zhu et al., Neurochem Int 2001
:
TGF-beta1 inhibits
caspase-3 activation and neuronal apoptosis in rat hippocampal cultures ... The present study attempted to identify whether
TGF-beta1 can
prevent neuronal apoptosis and interrupt
caspase-3 activation in rat primary hippocampal cultures after staurosporine treatment ... Furthermore,
TGF-beta1 ( 1 and 10 ng/ml ) markedly
inhibited the activation of
caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting
Kim et al., Oncogene 2001
(Stomach Neoplasms) :
Taken together, our results suggest that
activation of
caspase-3 by
TGF-beta1 may initiate the conversion from G1 cell cycle arrest to apoptosis via the cleavage of p21, p27 and Rb, which in turn causes Cdk2 activation and, most significantly, Cdk2 activation as a downstream effector of caspase is a critical step for the execution of TGF-beta1 induced apoptosis
Cain et al., Toxicol Lett 2001
:
However the mechanism by which
TGF-beta(1) induces
caspase activation and cell death is unknown
Hayashida-Hibino et al., Invest Ophthalmol Vis Sci 2001
:
Furthermore, Western blot analysis revealed that
TGF-beta1 remarkably decreased PAI-2, transferrin receptor, and integrin alpha3, and
increased caspase10 on the protein level
Herrera et al., Hepatology 2001
:
Our results show that
TGF-beta1 activates at least
caspase-3 , -8, and -9 in rat fetal hepatocytes, which are not required for ROS production, glutathione depletion, bcl-xL down-regulation, and initial cytochrome c release
Negulescu et al., Kidney Int 2002
:
The
effects of
TGF-beta1 on mesangial cell apoptosis, p53 phosphorylation, Bax and Bcl-2 levels,
caspase 9 activity, and cleavage of PARP were examined
Coyle et al., J Biol Chem 2003
(Carcinoma, Hepatocellular...) :
We have previously shown that
transforming growth factor-beta(1) ( TGF-beta(1) ) -induced apoptosis in FaO hepatoma cells is
mediated by cytochrome c release, apoptosome formation, and
caspase activation ... A second delayed response cluster ( 44 genes ) was also observed when
TGF-beta(1) induced
caspase activation was blocked by benzyloxycarbonyl-VAD-fluoromethyl ketone
Albright et al., Exp Mol Pathol 2003
(Cell Transformation, Viral) :
TGFbeta1-apoptosis was significantly reduced when cells were treated with
TGFbeta1 in the
presence of inhibitors of
caspase-1 , -3, -8, and -9
Kim et al., J Biol Chem 2004
(Carcinoma, Hepatocellular...) :
In contrast, overexpression of the dominant negative MLK3 resulted in suppression of
TGF-beta1 induced MAP kinase activation and TGF-beta1 induced
caspase-3 activation
Wang et al., Carcinogenesis 2005
:
This effect is dependent on RON expression and phosphorylation that inhibit the
TGF-beta1 induced activation of
caspase-3 and truncation of BAD ... PD98059 also prevented the inhibitory effect of RON on
TGF-beta1 induced cleavage of
caspase-3 and BAD
Guo et al., World J Gastroenterol 2005
:
TGF-beta1 induced apoptosis was associated with the phosphorylation of p38, and SB202190, a specific inhibitor of p38, which was able to inhibit
TGF-beta1 induced
caspase activation and apoptosis
Kim et al., Exp Mol Med 2007
:
TGF-beta1 induced early increase of
caspase-3 activity
Nastiuk et al., Mol Cancer Res 2008
:
TGFbeta1 induced
caspase-3 activity is proportional to the level of cell death and inversely proportional to the level of FLIP expression in various clones
Park et al., Mol Carcinog 2008
(Carcinoma, Hepatocellular...) :
The
TGFbeta1 induced
caspase-3 activation was also suppressed in Huh-7 and FaO cells both transduced with PTN gene bearing adenoviruses
Lu et al., Am J Physiol Lung Cell Mol Physiol 2009
:
While caspase-12 activity was not altered,
caspase-8 was
activated by
TGF-beta1 , an effect that correlated with a reduction of cFLIP protein levels
Houde et al., J Biol Chem 2009
:
The expression of activated
caspase-9 , but not that of caspase-8, was
increased by
TGF-beta1 stimulation, and the rate of TGF-beta1 induced apoptosis was significantly lower in the presence of a caspase-9 inhibitor
Yoshikawa et al., Eur J Pharmacol 2010
(MAP Kinase Signaling System) :
TSA prevented
TGF-beta1 induced apoptosis and the
activation of caspase-8 and
caspase-9 in RPTECs but did not inhibit the TGF-beta1 induced phosphorylation of Smad3 and p38 mitogen activated protein kinase ( MAPK )