◀ Back to MAPK8
MAPK8 — TRAF6
Pathways - manually collected, often from reviews:
-
BioCarta bone remodeling:
TRAF6
→
JNK1 (MAPK8)
(modification, activates)
-
KEGG Neurotrophin signaling pathway:
TRAF6
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Tuberculosis:
TRAF6
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
NCI Pathway Database p75(NTR)-mediated signaling:
JNK family (MAPK8/MAPK9/MAPK10)
→
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Khursigara et al., J Neurosci 2001, Gentry et al., J Biol Chem 2004, Yeiser et al., J Neurosci 2004, Linggi et al., J Biol Chem 2005, Casaccia-Bonnefil et al., Nature 1996
Evidence: mutant phenotype, assay, reporter gene, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
JNK family (MAPK8/MAPK9/MAPK10)
→
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Khursigara et al., J Neurosci 2001, Yeiser et al., J Neurosci 2004, Linggi et al., J Biol Chem 2005
Evidence: mutant phenotype, reporter gene, other species
-
Reactome Reaction:
MAPK8
→
TRAF6
(reaction)
-
WikiPathways EBV LMP1 signaling:
Complex of MAP3K7-TAB1-MAP3K3-TRAF6
→
MAPK8
(activation)
-
WikiPathways Apoptosis Modulation and Signaling:
TRAF6
→
MAPK8
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Pullen et al., J Biol Chem 1999
:
In contrast, p38
mitogen activated protein kinase activation was primarily
dependent upon
TRAF6 binding
Schultheiss et al., EMBO J 2001
(Cell Transformation, Viral...) :
In TRAF6-knockout fibroblasts, significant induction of p38
MAPK by LMP1 is
dependent on the ectopic expression of
TRAF6
Li et al., American journal of physiology. Renal physiology 2002
:
TRAF6 , in turn,
activates SAPK/JNK and p38
MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells
Matsuyama et al., J Immunol 2003
(MAP Kinase Signaling System) :
Transfection of differentiated DDR1b overexpressing THP-1 cells with dominant negative TRAF6 completely abrogated DDR1b mediated p38 MAPK phosphorylation, indicating a critical
role of
TRAF6 in DDR1b mediated p38
MAPK activation
Mason et al., Infect Immun 2004
:
TRAF6 dependent
mitogen activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Horie et al., Microbes Infect 2007
(HIV Infections) :
TRAF activation of C/EBPbeta ( NF-IL6 ) via p38
MAPK induces HIV-1 gene expression in monocytes/macrophages
Funakoshi-Tago et al., Cytokine 2009
:
On the other hand,
TRAF6 deficiency did not
affect the TNFalpha induced activation of
mitogen activated protein ( MAP ) kinases , ERK, JNK, and p38
Avila et al., Innate Immun 2012
:
Lyn kinase controls TLR4 dependent IKK and
MAPK activation
modulating the activity of
TRAF-6/TAK-1 protein complex in mast cells