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CSF1 — PIK3CA
Text-mined interactions from Literome
Kelley et al., J Biol Chem 1999
:
In normal human monocytes,
M-CSF increased the levels of tyrosine phosphorylated proteins and induced Akt activation in a
PI3K dependent manner
Grey et al., Endocrinology 2000
:
Taken together, the current data suggest that c-src, via its SH3 domain, may participate in
CSF-1 induced activation of
PI3-K and that PI3-K and c-src are in the signaling pathway that subserves CSF-1 induced cytoskeletal changes in osteoclasts
Palacio et al., Eur J Endocrinol 2001
:
In murine osteoclast-like cells grown from bone marrow cells co-cultured with osteoblasts, the
activation of the
PI 3-K by
CSF-1 was determined both in vivo and in vitro ... In osteoclast-like cells,
CSF-1 stimulated
PI 3-K activity
Mandal et al., Endocrinology 2009
:
Inhibition of
PI3K/Akt signaling
blocked the binding of Smads 1/5 to the
CSF-1 BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription ... Together, these data for the first time demonstrate that
PI3K dependent Akt activation
regulates BMP-2 induced
CSF-1 expression and provides a mechanism for osteoblastic cell assisted osteoclast differentiation