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RB1 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → RB1 (transcriptional regulation, unknown)
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SP1 — RB1 (physical association, affinity chromatography technology) Singh et al., Oncogene 2002*
• IRef Biogrid Interaction: SP1 — RB1 (physical association, affinity chromatography technology) Chang et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: SP1 — RB1 (physical association, affinity chromatography technology) Opitz et al., Cancer Res 2000*
• IRef Hprd Interaction: SP1 — RB1 (in vivo) Opitz et al., Cancer Res 2000*, Udvadia et al., Proc Natl Acad Sci U S A 1995*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Singh et al., Oncogene 2002*
• IRef Intact Interaction: Complex of 248 proteins (association, pull down) von Eyss et al., EMBO J 2012
• IRef Ophid Interaction: SP1 — RB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Johnson-Pais et al., Proc Natl Acad Sci U S A 2001 : pRB induces Sp1 activity by relieving inhibition mediated by MDM2 ... These results suggest a model in which the opposing activities of MDM2 and pRB regulate Sp1 DNA binding and transcriptional activity
Guo et al., J Biol Chem 2003 : Recently, we found that MDM2 interacts with Sp1 and inhibits Sp1 dependent transcription and that pRb can restore Sp1 activity by displacing MDM2 from Sp1 ( 2 )
Zhao et al., BMC cancer 2005 : It has recently been reported that pRB induces Sp1 activity by relieving inhibition mediated by mdm2