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CDC42 — GRAP2

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: LAT/GRAP2/SLP76/VAV1/NCK1 complex (LAT-GRAP2-LCP2-VAV1-NCK1) → CDC42/GDP complex (CDC42) (modification, activates) Zeng et al., J Immunol 2003, Aspenström et al., Curr Biol 1996, Crespo et al., Nature 1997
  Evidence: assay

Text-mined interactions from Literome

Philips et al., J Biol Chem 2000 : Differential effect of Rac and Cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts
Lamalice et al., Oncogene 2004 : Moreover, the expression of a dominant negative form of Cdc42 ( Cdc42 N17 ) inhibited the activation of SAPK2/p38 and of its direct target MAP kinase activated protein kinase 2
Fessler et al., J Biol Chem 2004 : Methyl-beta-cyclodextrin induces activation of p38 and Cdc42 , but not Rac, in the nonstimulated PMN, yet inhibits subsequent lipopolysaccharide induced activation of p38 and Cdc42
Chan et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Overexpression of a PAK inhibitory peptide or dominant negative Cdc42 revealed that p38 activation was dependent on PAK and Cdc42 activities
Gamell et al., PloS one 2011 : These signaling effects on p38/MK2/Hsp25 do not require the activity of either Cdc42 or PAK, whereas p38/MK2 activities do not significantly modify the BMP-2 dependent activation of LIMK1, measured by either kinase activity or with an antibody raised against phospho-threonine 508 at its activation loop