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NFKB1 — S100A4

Text-mined interactions from Literome

Yammani et al., Arthritis Rheum 2006 : Stimulation of chondrocytes with S100A4 increased the phosphorylation of Pyk-2, MAP kinases, and activated NF-kappaB , followed by increased production of MMP-13 in the conditioned medium
Grotterød et al., BMC cancer 2010 (Osteosarcoma) : Signal transduction mechanisms involved in S100A4 induced activation of the transcription factor NF-kappaB ... The metastasis promoting protein S100A4 activates the transcription factor NF-kappaB through the classical NF-kappaB activation pathway ... The Ser/Thr kinase inhibitors H-7 and staurosporine inhibited S100A4 induced IkappaBalpha phosphorylation and subsequent NF-kappaB activation ... Dominant negative MEKK1 or NIK did not inhibit S100A4 induced NF-kappaB activity, and S100A4 stimulation did not influence AKT phosphorylation ... S100A4 activates NF-kappaB by inducing phosphorylation of IKKalpha/beta, leading to increased IkappaBalpha phosphorylation ... The Ser/Thr kinase inhibitors H-7 and staurosporine attenuated S100A4 induced NF-kappaB activation and inhibited IKK mediated phosphorylation of IkappaBalpha ... S100A4 induced NF-kappaB activation was independent of the putative S100 protein receptor RAGE and the Ser/Thr kinases MEKK1, NIK and AKT