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BCL2 — CD4

Text-mined interactions from Literome

Verschelde et al., Cell Death Differ 2003 : Activation of CD4 ( + ) or CD8 ( + ) T cells by antigenic peptides induced an early but transient IL-2 independent expression of A1 and Bcl-xl mRNA and proteins, whereas expression of Bcl-2 was delayed and required IL-2
Gratiot-Deans et al., Proc Natl Acad Sci U S A 1994 : These studies show that ( i ) expression of a transgenic TCR in double negative thymocytes does not lead to premature loss of Bcl-2 ; thus, Bcl-2 downregulation is not solely due to TCR expression ; ( ii ) Bcl-2 expression is lost at the early transitional CD3-/loCD4-CD8+ stage, prior to expression of CD4 ; ( iii ) the Bcl-2+ double positive thymocytes are those which have undergone positive selection ; and ( iv ) upregulation of Bcl-2 during positive selection requires participation of the CD4 or CD8 co-receptor ... These results demonstrate that Bcl-2 and TCR expression are regulated independently during T-cell development, and suggest a role for the CD4 or CD8 co-receptor in Bcl-2 induction during positive selection
Hashimoto et al., Blood 1997 (HIV Infections) : Here we demonstrate that CD4XL mediated by both, anti-CD4 monoclonal antibody ( MoAb ) or human immunodeficiency virus ( HIV ) envelope protein gp120 reduces the expression of the proto-oncogene Bcl-2 in CD4+ T cells, but not in CD8+ T cells, concurrently with the induction of CD4+ T cell-apoptosis ... Addition of interleukin (IL)-2 rescued CD4+ T cells from CD4XL induced Bcl-2 downmodulation and apoptosis induction