◀ Back to RELA
RELA — STAT5A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nakamura et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Analyzing the effects of several inhibitors or mutant receptors revealed that this
NF-kappa B activation is
mediated neither by MEK/ERK/MAPK nor by the phosphatidylinositol 3-kinase pathway but by
STAT5 ... In addition,
STAT5 dependent
NF-kappa B activation is mediated not through an inducible nuclear translocation but via up-regulation of both DNA binding activity and transactivation potential of NF-kappa B
Hinz et al., J Exp Med 2002
(Hodgkin Disease) :
Intriguingly,
NF-kappaB positively
regulates STAT5a expression and signaling pathways in HRS cells, and promotes its persistent activation
Giron-Michel et al., Blood 2003
:
Differential STAT3,
STAT5 , and
NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15 : implications in the expression of functional molecules
Nagy et al., Molecular cancer 2009
(Lymphoma) :
Moreover, depletion of
STAT5 via selective antisense oligonucleotide treatment similarly
resulted in decreased BCL10 mRNA and protein expression, cellular viability and impaired
NFkappaB activity independent of IL-2