Olanrewaju et al., Am J Physiol 1992
:
IGF-I and IGF-II, but not insulin, were potent ( half-maximal effective concentration 0.3 nM ) and efficacious inducers of the growth related enzyme ornithine decarboxylase (ODC) in the gut derived cell line IEC-6
Huber et al., Mol Cell Endocrinol 1996
(Breast Neoplasms) :
IGF-1 and PMA additively increased ODC mRNA level, whereas E2 alone had no effect on ODC mRNA abundance
Tørring et al., J Urol 1997
:
The ODC-activity in the prostate was significantly increased by IGF-I after 3 days of treatment, and administration of IGF-I concomitantly with DFMO significantly inhibited ODC activity and the weight increase of the prostate