Gene interactions and pathways from curated databases and text-mining

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HSPG2 — LPL

Pathways - manually collected, often from reviews:

  • Reactome Reaction: LPL → HSPG2 (indirect_complex)

Text-mined interactions from Literome

Braun et al., Am J Physiol 1991 (Diabetes Mellitus, Experimental) : Diabetes also reduced the PLC induced release of LPL
Doroudi et al., J Steroid Biochem Mol Biol 2012 : LPL activates phospholipase C (PLC) , and resulting inositol trisphosphate ( IP ( 3 ) ) and diacylglycerol contribute to PKCa activation and downstream activation of ERK1/2
Chajek-Shaul et al., Biochim Biophys Acta 1989 : The effect of phosphatidylinositol-specific phospholipase C ( PI-PLC ) on the release of lipoprotein lipase was studied in F1 heart cell cultures ... As there is a previously described correlation between circulating LPL and the heparin-releasable LPL, we hypothesize that the activity of PI-PLC in the endothelial cell membrane or plasma phosphatidyl-specific phospholipase D regulates the plasma LPL levels