Glass et al., Dev Cell 2005
(Osteopetrosis) :
Cellular and molecular studies showed that beta-catenin together with TCF proteins regulates osteoblast expression of Osteoprotegerin , a major inhibitor of osteoclast differentiation
Glass et al., Ann N Y Acad Sci 2006
(Bone Resorption) :
Cellular and molecular studies showed that beta-catenin together with TCF proteins regulates in osteoblasts the expression of Osteoprotegerin , a major inhibitor of osteoclast differentiation
De Toni et al., Clin Cancer Res 2008
(Colonic Neoplasms...) :
OPG is regulated by beta-catenin and mediates resistance to TRAIL induced apoptosis in colon cancer
Sato et al., Genes Cells 2009
:
Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling induced osteoprotegerin expression ... OPG expression was induced by Wnt/beta-catenin signaling in C2C12 cells and osteoblastic MC3T3-E1 cells ... Deletion and mutation analysis revealed that Wnt/beta-catenin signaling regulates transcription of OPG via a promoter region containing two Wnt/beta-catenin responsive sites ... BMP-2 enhanced Wnt/beta-catenin dependent transcriptional activation of the OPG promoter
Suda et al., Oral Microbiol Immunol 2009
:
Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha stimulated periodontal ligament cells ... The purpose of this study was to examine the roles of beta-catenin and AP-1 in interleukin-1alpha (IL-1alpha) -induced OPG production in human gingival fibroblasts ( hGFs ) and periodontal ligament ( PDL ) cells ... The present study suggests that beta-catenin enhances IL-1alpha induced OPG production in both PDL cells and hGFs, whereas AP-1 suppresses IL-1alpha induced OPG production in PDL cells