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IGF1R — VEGFA
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC
→
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
-
WikiPathways Focal Adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC
→
BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1
(activation)
Text-mined interactions from Literome
Neid et al., J Biol Chem 2004
(Adenocarcinoma...) :
Taken together, our results show that in AsPC-1 pancreatic carcinoma cells, Sp1 dependent
VPF/VEGF transcription is
controlled by
IGF-1R signaling through IRS-2 proteins and modulated by a negative feedback loop of PKC-zeta to IRS-2
Jiang et al., Invest Ophthalmol Vis Sci 2010
:
Overall, beta-adrenergic receptor antagonism produced a dysfunctional ERG, which occurred with an increase in
IGF-1R phosphorylation and
activation of
VEGF
Jiang et al., Can J Physiol Pharmacol 2010
(Diabetes Mellitus, Experimental) :
Since
insulin/insulin-like growth factor 1 receptor ( IGF-1R ) can
activate vascular endothelial growth factor to promote vascular growth, reduced IGF-1R signaling in the type I diabetic heart could be detrimental, leading to reduced, collateral blood vessel growth
Spiliotaki et al., Lung Cancer 2011
(Carcinoma, Non-Small-Cell Lung...) :
Targeting the
insulin-like growth factor I receptor inhibits proliferation and
VEGF production of non-small cell lung cancer cells and enhances paclitaxel mediated anti-tumor effect
Goel et al., Cancer Discov 2012
(Prostatic Neoplasms) :
VEGF/NRP2 signaling
represses insulin-like growth factor-1 receptor ( IGF-IR ) expression and signaling, and the mechanism involves Bmi-1 mediated transcriptional repression of the IGF-IR