Gene interactions and pathways from curated databases and text-mining

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IGF1R — VEGFA

Pathways - manually collected, often from reviews:

  • KEGG Focal adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC → EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  • WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)

Text-mined interactions from Literome

Neid et al., J Biol Chem 2004 (Adenocarcinoma...) : Taken together, our results show that in AsPC-1 pancreatic carcinoma cells, Sp1 dependent VPF/VEGF transcription is controlled by IGF-1R signaling through IRS-2 proteins and modulated by a negative feedback loop of PKC-zeta to IRS-2
Jiang et al., Invest Ophthalmol Vis Sci 2010 : Overall, beta-adrenergic receptor antagonism produced a dysfunctional ERG, which occurred with an increase in IGF-1R phosphorylation and activation of VEGF
Jiang et al., Can J Physiol Pharmacol 2010 (Diabetes Mellitus, Experimental) : Since insulin/insulin-like growth factor 1 receptor ( IGF-1R ) can activate vascular endothelial growth factor to promote vascular growth, reduced IGF-1R signaling in the type I diabetic heart could be detrimental, leading to reduced, collateral blood vessel growth
Spiliotaki et al., Lung Cancer 2011 (Carcinoma, Non-Small-Cell Lung...) : Targeting the insulin-like growth factor I receptor inhibits proliferation and VEGF production of non-small cell lung cancer cells and enhances paclitaxel mediated anti-tumor effect
Goel et al., Cancer Discov 2012 (Prostatic Neoplasms) : VEGF/NRP2 signaling represses insulin-like growth factor-1 receptor ( IGF-IR ) expression and signaling, and the mechanism involves Bmi-1 mediated transcriptional repression of the IGF-IR