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AR — CTNNB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AR → CTNNB1 (directlyIncreases, CTNNB1 Activity) Sharma et al., J Biol Chem 2002*
  Evidence: Moreover, we show that the repression of AR activity by LY294002 is mediated through phosphorylation and inactivation of GSK3beta, a downstream substrate of PI3K/Akt, which results in the nuclear accumulation of beta-catenin The activation of Akt results in the phosphorylation of a number of downstream substrates such as glycogen synthase kinase (GSK3) It has been shown that GSK3 plays an important role in the Wnt pathway by regulating the degradation of -catenin Recently, a specific protein-pro...
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → beta catenin/AR/T-DHT/TIF2 complex (CTNNB1-AR-NCOA2) (modification, collaborate)
  Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4/beta catenin complex (TCF7L2-CTNNB1) → AR/T-DHT complex (AR) (modification, collaborate) Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF4 (TCF7L2) → beta catenin/AR/T-DHT/TIF2 complex (CTNNB1-AR-NCOA2) (modification, collaborate)
  Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: beta catenin/AR/T-DHT/TIF2 complex (CTNNB1-AR-NCOA2) → AR/T-DHT complex (AR) (modification, collaborate) Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: beta catenin/AR/T-DHT/TIF2 complex (CTNNB1-AR-NCOA2) → TIF2 (NCOA2) (modification, collaborate) Yang et al., J Biol Chem 2002, Li et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Coregulation of Androgen receptor activity: beta catenin (CTNNB1) → AR/T-DHT complex (AR) (transcription, activates) Yang et al., J Biol Chem 2002
  Evidence: mutant phenotype, reporter gene

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — AR (direct interaction, pull down) Yang et al., J Biol Chem 2002
• IRef Biogrid Interaction: CTNNB1 — AR (direct interaction, two hybrid) Yang et al., J Biol Chem 2002
• IRef Biogrid Interaction: CTNNB1 — AR (direct interaction, two hybrid) Masiello et al., Mol Endocrinol 2004*
• IRef Biogrid Interaction: CTNNB1 — AR (direct interaction, two hybrid) Song et al., Mol Endocrinol 2004*
• IRef Biogrid Interaction: CTNNB1 — AR (direct interaction, pull down) Amir et al., J Biol Chem 2003*
• IRef Biogrid Interaction: CTNNB1 — AR (physical association, affinity chromatography technology) Amir et al., J Biol Chem 2003*
• IRef Biogrid Interaction: CTNNB1 — AR (physical association, affinity chromatography technology) Mulholland et al., Oncogene 2003*
• IRef Biogrid Interaction: CTNNB1 — AR (direct interaction, pull down) Mulholland et al., Oncogene 2003*
• IRef Biogrid Interaction: CTNNB1 — AR (physical association, affinity chromatography technology) Pawlowski et al., J Biol Chem 2002*
• IRef Dip Interaction: AR — CTNNB1 (direct interaction, pull down) Yumoto et al., Proc Natl Acad Sci U S A 2012*
• IRef Hprd Interaction: AR — CTNNB1 (in vivo) Pawlowski et al., J Biol Chem 2002*, Song et al., Mol Cell Biol 2003*, Amir et al., J Biol Chem 2003*, Mulholland et al., Oncogene 2003*
• IRef Hprd Interaction: AR — CTNNB1 (in vitro) Pawlowski et al., J Biol Chem 2002*, Song et al., Mol Cell Biol 2003*, Amir et al., J Biol Chem 2003*, Mulholland et al., Oncogene 2003*
• IRef Hprd Interaction: AR — CTNNB1 (two hybrid) Pawlowski et al., J Biol Chem 2002*, Song et al., Mol Cell Biol 2003*, Amir et al., J Biol Chem 2003*, Mulholland et al., Oncogene 2003*
• IRef Innatedb Interaction: AR — CTNNB1 (unknown, -) Chen et al., Mol Cell Biol 2006*
• IRef Intact Interaction: Complex of 19 proteins (association, pull down) Zhuo et al., Mol Endocrinol 2011*
• IRef Intact Interaction: AR — CTNNB1 (physical association, anti bait coimmunoprecipitation) Truica et al., Cancer Res 2000*
• IRef Intact Interaction: AR — CTNNB1 (physical association, anti bait coimmunoprecipitation) Song et al., Mol Cell Biol 2003*
• IRef Intact Interaction: AR — CTNNB1 (physical association, two hybrid) Song et al., Mol Cell Biol 2003*
• IRef Intact Interaction: AR — CTNNB1 (direct interaction, pull down) Song et al., Mol Cell Biol 2003*
• IRef Intact Interaction: AR — CTNNB1 (association, anti bait coimmunoprecipitation) Ni et al., Cancer Cell 2011*
• IRef Intact Interaction: AR — CTNNB1 (colocalization, confocal microscopy) Ni et al., Cancer Cell 2011*
• IRef Intact Interaction: AR — CTNNB1 (direct interaction, pull down) Zhuo et al., Mol Endocrinol 2011*
• IRef Ophid Interaction: AR — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: AR — CTNNB1 (aggregation, confirmational text mining) Pawlowski et al., J Biol Chem 2002*

Text-mined interactions from Literome

Truica et al., Cancer Res 2000 (Prostatic Neoplasms) : Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
Song et al., Mol Cell Biol 2003 : We also demonstrated cross talk between the WNT and androgen receptor signaling pathways because excess androgen receptor could interfere with WNT signaling and excess TCF-4 inhibited the interaction of beta-catenin and androgen receptor
Lévy et al., Mol Cell Biol 2004 : Our data suggest that acetylation of beta-catenin in the arm 6 domain regulates beta-catenin transcriptional activity by differentially modulating its affinity for Tcf4 and the androgen receptor
Tycko et al., Curr Mol Med 2007 (Prostatic Neoplasms...) : Beta-catenin gain-of-function mutations are strongly linked to WT1 loss-of-function mutations in syndromic Wilms tumors, and Wnt/beta-catenin signaling increases androgen receptor mRNA expression and blocks apoptosis in prostate cancers