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APOE — PTGS2

Text-mined interactions from Literome

Guo et al., J Mol Neurosci 2004 (Alzheimer Disease...) : Apolipoprotein E3 (apoE3) and apoE4 suppressed oligomeric Abeta induced production of inducible nitric oxide synthase and cyclo-oxygenase-2 , supporting an anti- inflammatory role for apoE
Kawamura et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : IL-1beta induced expression and activation of inducible nitric oxide synthase and cyclooxygenase-2 were inhibited by apoE in vascular smooth muscle cells ( VSMCs )
Ali et al., Atherosclerosis 2008 : Finally, the effect of apoE on COX-2 was found to be independent of expression on the VSMC surface of the LDL receptor and heparan sulfate proteoglycans (HSPG)
Samy et al., J Mol Neurosci 2012 (Alzheimer Disease...) : Regulation of IL-1ß induced cyclooxygenase-2 expression by interactions of Aß peptide, apolipoprotein E and nitric oxide in human neuroglioma ... We have used the human H4 neuroglioma cells as a model astroglial system to examine the interactions between IL-1ß and nitric oxide ( NO ) as co-stimulators of Aß ( 1-40 ) in enhancing the expression of COX-2 and production of PGE ( 2 ) in the presence of recombinant human apolipoprotein E4 (apoE4)
Kothapalli et al., Atherosclerosis 2013 : apoE3 upregulated expression of the cdk inhibitor, p27 ( kip1 ), in primary VSMCs, and this effect required Cox2 and activation of PGI(2)-IP signaling