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CTF1 — STAT3

Text-mined interactions from Literome

Fukuzawa et al., Hypertension 2000 (Cardiomegaly) : Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine loop for hypertrophy ... Cardiotrophin-1 induced STAT3 tyrosine phosphorylation and binding to the St-domain were suppressed by AG490, a specific JAK2 inhibitor, which also attenuated cardiotrophin-1 stimulated angiotensinogen promoter activity
Hamanaka et al., Circ Res 2001 (Hypotension) : Forced expression of JAB or CIS3, but not other CISs, directly blocked CT-1 induced STAT3 activation in 293 cells
Langdon et al., J Immunol 2003 (Pulmonary Eosinophilia) : Cell signaling studies showed that murine OSM, LIF, IL-6, and CT-1 stimulated the tyrosine phosphorylation of STAT-3 , suggesting STAT-3 activation is not sufficient for eotaxin induction in NIH 3T3 cells
Freed et al., Mol Cell Biochem 2003 (Disease Models, Animal...) : CT-1 induced rapid phosphorylation of Jak, Jak2, STAT1, STAT3 , p42/44 MAPK and Akt in cultured adult cardiac fibroblasts
Tian et al., Acta Pharmacol Sin 2004 (Cardiomegaly) : CT-1 simultaneously activated phosphorylation of STAT3 , ERK1/2, and PI3-K in rat cardiomyocytes ... The hypertrophic effect of CT-1 was essentially mediated by STAT3 , independent of PI3-K, and negatively regulated by ERK1/2 via inhibiting the phosphorylation of STAT3
Li et al., Chin Med J (Engl) 2004 (Cardiomegaly) : In this study, we examined whether STAT3 activity was negatively regulated by ERK1/2 during CT-1 induced signaling in rat cardiomyocytes and, if so, whether such crosstalk interfered with the hypertrophic effect of CT-1 and, furthermore, whether the mechanism underlying the crosstalk involved phosphorylation of serine 727 ( S727 ) in STAT3 ... CT-1 simultaneously activated both ERK1/2 and STAT3 in rat cardiomyocytes ... Inhibition of ERK1/2 by U0126 resulted in an increase of CT-1 induced tyrosine phosphorylation of STAT3 and, consequently, the protein-to-DNA ratio and [ ( 3 ) H ] -leucine incorporation ... Transient transfection of the cells with STAT3S727A had no significant effect on CT-1 induced tyrosine phosphorylation of STAT3 ... STAT3 is activated by CT-1 in rat cardiomyocytes, but full activation is mitigated by the simultaneous activation of ERK1/2
Takahashi et al., J Mol Cell Cardiol 2005 (Cardiomegaly...) : Overexpression of dominant negative STAT3 mutant suppressed CT-1 induced STAT3 phosphorylation, but did not affect cell hypertrophy ... On the other hand overexpression of SOCS1 or SOCS3 inhibited both CT-1 induced STAT3 phosphorylation and cell hypertrophy
Fritzenwanger et al., Cytokine 2006 : CT-1 induced concentration dependent phosphorylation of STAT3 without any change in total-STAT3 concentration