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RAC1 — TRIO
Pathways - manually collected, often from reviews:
-
BioCarta rac1 cell motility signaling pathway:
0005085 (ARHGEF1/TRIO/VAV1/ARHGEF5/CACNA1A)
→
RAC1
(modification, activates)
-
NCI Pathway Database Netrin-mediated signaling events:
RAC1/GDP complex (RAC1)
→
TRIO (TRIO)
(modification, collaborate)
Briançon-Marjollet et al., Mol Cell Biol 2008, Peng et al., J Biol Chem 2010*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Regulation of RAC1 activity:
RAC1/GDP complex (RAC1)
→
TRIO (TRIO)
(modification, collaborate)
Bellanger et al., Nat Cell Biol 2000*, Zhang et al., Biochem Biophys Res Commun 2005*, Charrasse et al., Mol Biol Cell 2007*, Briançon-Marjollet et al., Mol Cell Biol 2008, Debant et al., Proc Natl Acad Sci U S A 1996*
Evidence: assay
-
Reactome Reaction:
TRIO
→
RAC1
(reaction)
Harrington et al., J Neurosci 2002, Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008
-
Reactome Reaction:
TRIO
→
RAC1
(indirect_complex)
Li et al., Nat Neurosci 2008, Briançon-Marjollet et al., Mol Cell Biol 2008
-
WikiPathways Regulation of Microtubule Cytoskeleton:
TRIO
→
RAC1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TRIO
—
RAC1
(direct interaction, pull down)
Gao et al., J Biol Chem 2001*
-
IRef Dip Interaction:
RAC1
—
TRIO
(direct interaction, pull down)
Chen et al., Proc Natl Acad Sci U S A 2011*
-
IRef Hprd Interaction:
TRIO
—
RAC1
(in vivo)
Gao et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
TRIO
—
RAC1
(in vitro)
Gao et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
RAC1
—
TRIO
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
RAC1
—
TRIO
(aggregation, confirmational text mining)
Gao et al., J Biol Chem 2001*
Text-mined interactions from Literome
Debreceni et al., J Biol Chem 2004
:
The N1406A/D1407A mutant of
Trio acted dominant negatively in vitro by retaining Rac1 binding activity but losing GEF catalytic activity and competitively
inhibited Rac1 activation by wild type Trio
Briançon-Marjollet et al., Mol Cell Biol 2008
:
Trio mediates netrin-1 induced
Rac1 activation in axon outgrowth and guidance ... Here, we show that the RhoGEF
Trio mediates
Rac1 activation in netrin-1 signaling ... We found that Trio interacts with the netrin-1 receptor DCC in mouse embryonic brains and that netrin-1 induced
Rac1 activation in brain is
impaired in the absence of
Trio
Bach et al., Mol Biol Cell 2010
:
M-cadherin dependent pathways that signal through
Rac1 GTPase
activation via the Rho-guanine nucleotide exchange factor ( GEF )
Trio are important for myoblast fusion
Li et al., Genes & cancer 2011
:
Because knockdown of CDH11 prevents the plasma membrane localization of Trio, our study indicates that CDH11 may play a role in recruiting Trio to the plasma membrane where
Trio activates
Rac , leading to cell migration
van Rijssel et al., Mol Biol Cell 2012
:
Moreover, upon clustering of ICAM-1, the Rho-guanine nucleotide exchange factor
Trio activates
Rac1 , prior to activating RhoG, in a filamin dependent manner
van Rijssel et al., Cell Adh Migr 2012
:
We recently reported that the Rho-GEF
Trio , known to be able to exchange GTP on Rac1, RhoG and RhoA, regulates lamellipodia formation to mediate cell spreading and migration in a
Rac1 dependent manner
DeGeer et al., Mol Cell Biol 2013
:
The Rho guanine nucleotide exchange factor ( GEF )
Trio is
essential for
Rac1 activation downstream of netrin-1/DCC, but the molecular mechanisms governing Trio activity remain elusive
Bellanger et al., Oncogene 1998
:
To determine whether
Trio could
activate Rac1 and RhoA in vivo, we measured the effect of Trio on Mitogen Activated Protein Kinase ( MAPK ) pathways and cytoskeletal rearrangements events mediated by the two GTPases
Bellanger et al., C R Seances Soc Biol Fil 1998
:
[
Role of the multifunctional
Trio protein in the control of the
Rac1 and RhoA gtpase signaling pathways ]