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CLDN2 — IL13
Text-mined interactions from Literome
Weber et al., J Biol Chem 2010
(Inflammatory Bowel Diseases) :
In contrast,
IL-13 dependent
claudin-2 expression increases paracellular cation flux in vitro and in vivo without altering tight junction size selectivity but is unaffected by MLCK inhibition in vitro
Rosen et al., Inflamm Bowel Dis 2011
(Colitis, Ulcerative...) :
Cell transfection with STAT6 siRNA prevented
IL-13 induced apoptosis and
claudin-2 expression ... SAHA inhibited
IL-13 induced STAT6 phosphorylation, apoptosis, and
claudin-2 expression, and mitigated IL-13 induced reductions in transepithelial resistance
Rosen et al., J Immunol 2013
(Colitis, Ulcerative...) :
Similarly, short hairpin RNA STAT6 knockdown reduced
claudin-2 induction and transepithelial resistance decrease in
IL-13 treated human T84 cells