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CAB39 — PRKAG2
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PRKAG2
→
CAB39
(reaction)
Wojtaszewski et al., J Physiol 2000, Hawley et al., Journal of biology 2003, Woods et al., Curr Biol 2003, Shaw et al., Proc Natl Acad Sci U S A 2004, Rubink et al., J Appl Physiol 2005, Winder et al., Am J Physiol 1996
-
WikiPathways AMP-activated Protein Kinase (AMPK) Signaling:
Complex of STRADA-STRADB-STK11-CAB39
→
Complex of PRKAG3-PRKAA1-PRKAG2-PRKAG1-PRKAB2-PRKAB1-PRKAA2
(activation)
Text-mined interactions from Literome
Hawley et al., Journal of biology 2003
:
Second, both endogenous and recombinant complexes of LKB1, STRAD alpha/beta and MO25 alpha/beta activate
AMPK via phosphorylation of Thr172. Third, catalytically active LKB1, STRAD alpha or STRAD beta and
MO25 alpha or MO25 beta are
required for full activity
Ellingson et al., Am J Physiol Endocrinol Metab 2007
:
These results have identified 3-PG as an AMPK-specific regulator of
AMPK phosphorylation and
activation by
LKB1-STRAD-MO25