Gene interactions and pathways from curated databases and text-mining

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AKT1 — APP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ruiz-León et al., J Neurochem 2004 (Neuroblastoma) : Taken together, our results suggest that simultaneous activation of at least two signalling pathways, Ras/MAPK and PI3K/Akt , is necessary to mediate a full activation of the APP promoter by BDNF
Shineman et al., Biochemistry 2009 : Myr-Akt overexpression also resulted in increased APP protein stability