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FOS — RB1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of FOS-JUN
→
Complex of JUN-RB1
(increases)
Evidence: RB1&CEBPB^taof(CEBPB) Hypophosphorylated pRb binds c-Jun, JunD, and JunB (Nead et al., 1998). This enhances the binding of the Jun family members to c-Fos and stimulates transcriptional activation by the Fos:Jun complexes. A region (amino acids 612?657) in the B-pocket of pRb and a region in the C-pocket can independently bind c-Jun. The binding site in c-Jun is in the leucine zipper region.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
David et al., J Clin Invest 2005
(Bone Diseases, Metabolic...) :
However, in the absence of RSK2,
c-Fos dependent
osteosarcoma formation is impaired ... Therefore, RSK2 dependent stabilization of
c-Fos is
essential for
osteosarcoma formation in mice and may also be important for human osteosarcomas
Xiong et al., Diabetes 2010
(Hyperglycemia...) :
This inhibitory effect on feeding may be mediated by central mechanisms because
Rb1 stimulated
c-Fos expression in brain areas involved in energy homeostasis
Cheng et al., Food Chem Toxicol 2012
(MAP Kinase Signaling System) :
Taken together, our data suggest that ginsenoside
Rb1 is one of the effective components of GSS for the anti-osteoporosis activity and can inhibit osteoclastogenesis by suppressing RANKL induced activation of both JNK and p38 MAPKs and NF-?B pathways, and consequently down
regulating the gene expression of
c-Fos and NFATc1 in osteoclast precursors
Sunters et al., Dev Genet 1998
(Bone Neoplasms...) :
Control of cell cycle gene expression in bone development and during
c-Fos induced
osteosarcoma formation ... Prolonged activation of
c-Fos resulted in
osteosarcoma formation wherein the levels of cyclin D1, cyclin E, and CDKs 2, 4, and 6 were high in a wide spectrum of malignant cell types, especially in transformed osteoblasts