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ITGAV — TGFB3

Pathways - manually collected, often from reviews:

• Reactome Reaction: ITGAV → TGFB3 (indirect_complex) Ludbrook et al., Biochem J 2003, Kitamura et al., J Clin Invest 2011*
• Reactome Reaction: ITGAV → TGFB3 (reaction) Ludbrook et al., Biochem J 2003, Kitamura et al., J Clin Invest 2011*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM ITGAV-ITGB6-TGFB3 complex: ITGAV-ITGB6-TGFB3 complex complex (ITGAV-ITGB6-TGFB3) Annes et al., FEBS Lett 2002*
• IRef Corum Interaction: Complex of ITGB6-ITGAV-TGFB3 (association, affinity chromatography technology) Annes et al., FEBS Lett 2002*
• IRef Hprd Interaction: Complex of TGFB3-ITGB6-ITGAV-ITGB6-ITGAV-TGFB3-ITGB6-ITGAV-TGFB3 (in vivo) Annes et al., FEBS Lett 2002*
• IRef Ophid Interaction: ITGAV — TGFB3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Fjellbirkeland et al., Am J Pathol 2003 : Integrin alphavbeta8 mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue
Cambier et al., Am J Pathol 2005 : Integrin alpha(v)beta8 mediated activation of transforming growth factor-beta by perivascular astrocytes : an angiogenic control switch
Ganter et al., Circ Res 2008 (Pulmonary Edema...) : The results of in vitro studies indicated that IL-1beta caused the activation of transforming growth factor-beta via RhoA/alphavbeta6 integrin dependent mechanisms and the inhibition of the alphavbeta6 integrin and/or transforming growth factor-beta signaling completely blocked the IL-1beta mediated protein permeability across alveolar epithelial cell monolayers
Atarashi et al., Nature 2008 (Colitis...) : A CD70 ( high ) CD11c ( low ) subset of the lamina propria cells expresses T ( H ) 17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T ( H ) 17 differentiation of co-cultured naive CD4 ( + ) T cells
Xu et al., Am J Pathol 2009 (Fibrosis...) : Activation of latent transforming growth factor beta ( TGF-beta ) by alphavbeta6 integrin is critical in the pathogenesis of lung injury and fibrosis