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IRF6 — NOTCH1

Text-mined interactions from Literome

Kim et al., J Cell Sci 2008 : In the RAW264.7 macrophage cell line and in rat primary alveolar macrophages, LPS was found to inhibit Notch1 intracellular domain (Notch1-IC) transcription activity, which could then be rescued by treatment with N ( G ) -nitro-l-arginine, a nitric oxide synthase (NOS) inhibitor
Xing et al., J Cell Physiol 2010 : P-LPS stimulation activated the Notch1 signaling cascade and increased expression of the Notch target genes HES1 and HEY1
Outtz et al., J Immunol 2010 (Inflammation) : Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10, MCP-1, monokine induced by IFN-?, and TNF-a in macrophages in response to LPS/IFN-?
Zhang et al., J Biol Chem 2012 (Inflammation...) : The expression of Notch target genes including Hes1 and Hes5 was also induced in macrophages by LPS , suggesting that TLR4 signaling enhances the activation of Notch pathway
Larabee et al., J Biol Chem 2013 : Overexpression studies indicated that RBP-J was sufficient to activate Notch signaling and potentiate LPS induced Notch signaling