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IRF6 — MMP2

Text-mined interactions from Literome

Orucevic et al., Int J Cancer 1999 (Adenocarcinoma...) : In addition, there was up-regulation of MMP-2 , when extra NO was induced by IFN-gamma and LPS
Corbel et al., Pulm Pharmacol Ther 1999 (Inflammation...) : Nedocromil sodium ( 30 mg/kg, ip ) had no influence on the LPS induced MMP activities, on neutrophil recruitment, or on IL-10 level, but this drug elicited a significant inhibition of TNF- alpha level
Fenton et al., Osteoarthritis Cartilage 2000 (Horse Diseases...) : The addition of 25 mg/ml of glucosamine prevented the increase in nitric oxide production, proteoglycan release and MMP activity induced by LPS or rhIL-1
Nakatsuka et al., Life Sci 2000 : Both agents also suppressed matrix metalloproteinase-2 activity induced by LPS
Rosenberg et al., Brain Res 2001 (Brain Ischemia...) : The hydroxymate-type, MMP inhibitor, BB-1101, blocked the activation of MMP-2 and MMP-9 by LPS in mixed glial cultures
Corbel et al., Eur J Pharmacol 2001 (Acute Disease...) : These findings demonstrate that the two drugs can inhibit the in vivo increase in MMP induced by LPS , batimastat with a direct inhibitor effect on MMP activity and pirfenidone as a consequence of its antiinflammatory effect
Corbel et al., J Pharmacol Exp Ther 2002 (Lung Diseases) : In the first model, the lipopolysaccharide (LPS) induced increase in neutrophils, MMP-9 activity, and tumor necrosis factor (TNF)-alpha and TGF-beta release in bronchoalveolar lavage (BAL) was significantly reduced by RP 73-401 pretreatment
Harmey et al., Int J Cancer 2002 (Disease Models, Animal...) : LPS increased inducible nitric oxide synthase (iNOS) and MMP2 expression in lung tumor nodules
Lee et al., Glia 2003 : The expression of MMP-9 but not MMP-2 was increased by LPS
Lalu et al., Mol Cell Biochem 2003 (Cardiomyopathies...) : LPS also caused a loss of 72 kDa MMP-2 activity in the ventricles and the perfusate
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Tiranathanagul et al., J Periodontol 2004 (Alveolar Bone Loss) : We hypothesized that the LPS of A. actinomycetemcomitans could affect the activation of matrix metalloproteinase (MMP)-2 and the expression of receptor activator of nuclear factor kappa B ligand ( RANKL ) and osteoprotegerin in human periodontal ligament (HPDL) cells leading to the destruction of periodontium ... The activation of MMP-2 could be induced by the LPS of A. actinomycetemcomitans in HPDL cells and could be inhibited by a serine protease inhibitor ... This result suggested that the LPS might activate MMP-2 through a serine protease dependent pathway
Nareika et al., Am J Physiol Endocrinol Metab 2005 : Sodium lactate increases LPS stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities
Robinson et al., Shock 2006 (Endotoxemia) : As LPS induced gastric injury is mediated in part by iNOS, and NO modulates MMP production in vitro, we hypothesized that NOS inhibition would similarly modulate LPS induced gastric MMP production ... Therefore, the purpose of these studies was to compare the effects of selective and nonselective NOS inhibition on LPS induced gastric MMP production ... L-NAME failed to attenuate LPS induced gastric injury or MT1-MMP protein induction and increased MMP-2 levels
Kim et al., Arch Pharm Res 2007 (Periodontitis) : N-acetylcysteine prevents LPS induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts ... LPS enhanced ROS production, as well as, expression of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6, interleukin-8 and tumor necrosis factor-alpha, and the production and activation of MMP2
Alvarado et al., Cytokine 2008 : In this report, the effects of the bacterial lipopolysaccharide (LPS) and ECM bound IFN-gamma on MT1-MMP expression and MMP-2 activity were evaluated by Western blot, RT-PCR and zymography in isolated intestinal epithelial and cultured HT-29 cells ... In addition, the active form of MMP-2 was also decreased in the presence of both LPS and IFN-gamma, indicating that lower MMP-2 activity accompanied the decrease in MT1-MMP expression
Nareika et al., J Endocrinol 2008 : We have demonstrated recently that high glucose augments lipopolysaccharide (LPS) stimulated matrix metalloproteinase ( MMP ) and cytokine expression by U937 mononuclear cells and human monocyte derived macrophages
Cena et al., Eur J Pharmacol 2008 : LPS caused significantly greater MMP-2 activity in endothelium-intact aortae which was attenuated by doxycycline
Cheng et al., Mol Cell Biochem 2009 : Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system ; however, it is unknown if LPS is sufficient to upregulate expressions and/or activity of uPA, tPA, MMP-2 , and MMP-9 in myocardial cells ... In this study, we treated H9c2 cardiomyoblasts with LPS to explore whether LPS upregulates uPA, tPA, MMP-2 , and MMP-9, and further to identify the precise molecular and cellular mechanisms behind this upregulatory responses ... Here, we show that LPS challenge increased the protein levels of uPA, MMP-2 and MMP-9, and induced the activity of MMP-2 and MMP-9 in H9c2 cardiomyoblasts ... Collectively, these results suggest that LPS upregulates the expression and/or activity of uPA, MMP-2 , and MMP-9 through ERK1/2 signaling pathway in H9c2 cardiomyoblasts
Park et al., J Neuroimmunol 2009 (Encephalitis...) : KRG and GTS inhibited LPS induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells
Lirussi et al., Br J Pharmacol 2010 (Chorioamnionitis) : LPS induced over-expression of MMP2 and MMP9 in normal human myometrium was paralleled by an overactivity of the proteins
Ho et al., J Interferon Cytokine Res 2010 : Modulation of FLI-1 expression using either RNA interference or forced expression identified a positive role for FLI-1 in contributing to LPS induced expression of MMP-1, MMP-3 , MMP-10, and interleukin-10 (IL-10)
Hyc et al., Int J Mol Med 2011 : LPS increased the mRNA levels of IL-6, IL-1ß, TGF-ß1, MMP1a, MMP1b, MMP3 , MMP9, MMP13, MMP14, TIMP1 and TIMP3 while the mRNA levels of MMP2, TIMP2 and TIMP4 were significantly decreased
Wong et al., Invest Ophthalmol Vis Sci 2011 (Corneal Ulcer) : MMP-2 expression was not affected by LPS
Wu et al., Int J Cardiol 2012 (MAP Kinase Signaling System) : The aim of the present study was to evaluate the effect of Rosiglitazone on lipopolysaccharide (LPS) induced MMP-2 activation as well as its possible mechanism ... LPS induced MMP-2 activity was inhibited by Rosiglitazone ( PPAR? agonist ) in the rat aortic endothelial cells ( RAEC ) ... LPS induced MMP-2 activation was diminished due to exposure to NF-?B Activation Inhibitor II ( JSH-23 ) or Ras inhibitor, farnesylthiosalicylic acid (FTS) ... Our data shows that PPAR? agonist, Rosiglitazone suppresses LPS activated MMP-2 secretion via Ras-MEK1/2 signaling pathways and NF-?B activation
Jang et al., Arch Oral Biol 2011 (Inflammation...) : n-Butanol extracts of Panax notoginseng suppress LPS induced MMP-2 expression in periodontal ligament fibroblasts and inhibit osteoclastogenesis by suppressing MAPK in LPS activated RAW264.7 cells
Castro et al., Arterioscler Thromb Vasc Biol 2012 (Disease Models, Animal...) : LPS activated MMP-2 in the aorta by S-glutathiolation
Kraus et al., PloS one 2012 (Bacteroidaceae Infections...) : In cell cultures, LPS induced a significant up-regulation of interleukin (IL) 1ß, IL6, IL8, MMP1 and MMP3
Kuo et al., J Periodontal Res 2012 : In the presence of both CsA and LPS , the MMP activities inhibited by CsA could still be observed in the co-cultures ... In the individual cultures, in contrast, the CsA inhibited MMP activities, in the presence of LPS , were minimally detected ... This study demonstrated that, in co-cultures of human gingival fibroblasts and U937 macrophages, CsA could inhibit MMP activities in the presence of P. gingivalis LPS
Hsiao et al., Pediatr Blood Cancer 2013 (Hepatoblastoma...) : By contrast, LPS only down-regulated IL-8 production and MMP-2 gelatinolytic activity
McElroy et al., PloS one 2012 : LPS induction of COX-2 requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease ( MMP ) activity
Marquis et al., BMC complementary and alternative medicine 2012 (Periodontal Diseases) : The effects of auraptene and lacinartin on LPS induced cytokine and MMP secretion by macrophages were determined by immunological assays
Ko et al., Arch Oral Biol 2012 : Myricetin suppresses LPS induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL induced RAW 264.7 cells
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : LPS , IL-1a, and TNFa dose-dependently increased MMP-3, MMP-9 , and MMP-13 activity in cultured chondrocytes and in NLRP3 ( -/- ) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1ß
Lin et al., Shock 2013 (Acute Lung Injury) : In addition, LPS increased pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor a and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhanced the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2 , and MMP-9, whereas it decreased the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which were attenuated by SalB pretreatment
Lew et al., PloS one 2013 (Fibrosis) : LPS increased LV expression of collagen Ia1, collagen IIIa1, MMP2, MMP9 , TIMP1, periostin and IL-6 ( P < 0.05 moderate vs low dose LPS and vs control )
Ko et al., Biomaterials 2013 (Osteoarthritis) : Treatment with SFN-PLGA microspheres inhibited the mRNA and protein expression of COX-2, ADAMTS-5 and MMP-2 induced by LPS in articular chondrocytes
Iwata et al., PloS one 2013 (Intervertebral Disc Displacement...) : Further, lipopolysaccharide (LPS) induced expression of TNF-a, MMP3, MMP13 , VEGF, and PGES mRNA in the 3D cultures, creating a molecular milieu that mimics that of degenerated NP
Lively et al., Journal of neuroinflammation 2013 (Wounds and Injuries) : IL4 increased MMP2 and cathepsins S and K ; whereas LPS increased MMP9, MMP12 , MMP14 ( MT1-MMP ), heparanase, and cathepsin L1
Xie et al., J Immunol 1994 : Time course analyses revealed that LPS regulated the expression of MMP-9 and MMP-2 via discordant kinetics
Panagakos et al., J Endod 1996 : Little information is currently known regarding the effects of cytokines and lipopolysaccharides (LPS's) on matrix metalloproteinase ( MMP ) production by pulp cells in vitro
Shankavaram et al., J Leukoc Biol 1998 : These results provide evidence that tyrosine phosphorylation of cPLA2 is one of the initial steps needed for the LPS induced MMP production in human monocytes
Deb et al., J Neurosci Res 1999 (Brain Neoplasms...) : A beta, but not interleukin-1beta (IL-1beta) or lipopolysaccharide (LPS) , stimulated an active form of MMP-2 in human U87 glioblastoma cells, as well as increased the expression of the well-known activator of MMP-2, membrane-type ( MT ) -MMP