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Saura et al., J Neurochem 2003 : LPS induced dose dependent increases in apoJ and decreases in apoE expression and secretion with maximum effects at 1-10 ng/mL and 0.1-1 microg/mL, respectively ... Two NF-kappa B inhibitors, aspirin ( 10 mM ) and MG-132 ( 0.1 microM ), blocked basal apoE and apoJ secretion as well as LPS induced apoJ secretion ... These data demonstrate that glial apoE and apoJ expression are independently regulated by LPS in microglia and astroglia, respectively, and that activated microglia are the predominant source of apoE in mixed glial cultures ... The transcription factor NF-kappa B appears to be a critical mediator of LPS stimulated apoJ expression from astroglia
Nuutinen et al., Neurochem Int 2005 : Furthermore, LPS did not affect clusterin expression in N9 microglia although activated NF-kappaB signaling and IL-6 expression