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FGF2 — IL1A

Text-mined interactions from Literome

Ko et al., Mol Cell Probes 1999 : We could demonstrate in HUAEC that stimulation with IL-1alpha- and TNF-alpha led to the mRNA expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor ( VEGF ) which are crucial in the process of angioneogenesis and atherosclerosis as well as of the granulocyte-colony stimulating factor ( G-CSF ), granulocyte macrophage-colony stimulating factor ( GM-CSF ) and stem cell factor (SCF) which are main growth factors in haematopoiesis
Takahashi et al., J Pharmacol Exp Ther 1999 (Stomach Ulcer) : We investigated the role of endogenous interleukin (IL)-1 in the mRNA expression of cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS), cytokine induced neutrophil chemoattractant ( CINC ) -1, epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) , hepatocyte growth factor (HGF), and transforming growth factor (TGF)-beta1 in acetic acid induced gastric ulcers in rats ... In a culture of isolated ulcer bases, block of IL-1 with IL-1 receptor antagonist (IL-1RA) dose-dependently and significantly reduced the mRNA levels of COX-2, iNOS, CINC-1, HGF, and bFGF
Sobue et al., Biochem Biophys Res Commun 2001 (Osteoarthritis) : IL-1 increased FGF-2 mRNA expression in osteoblasts within 1.5 to 3 h. Multiple FGF-2 protein isoforms were expressed in human osteoblasts
Gallicchio et al., J Leukoc Biol 1992 (Retroviridae Infections) : In addition, synergistic activity of B-FGF on zidovudine induced hematopoietic stem cell toxicity was observed in the presence of interleukin 1 (IL-1) ( 30 ng/ml )
Lee et al., J Biol Chem 2004 (Inflammation) : IL-1 beta greatly increased the levels of FGF-2 mRNA in a time- and dose dependent manner ; IL-1 beta stimulated expression of all isoforms of FGF-2
Cozzolino et al., Proc Natl Acad Sci U S A 1990 (Neovascularization, Pathologic) : In an angiogenesis model, IL-1 could inhibit fibroblast growth factor induced vessel formation
Sato et al., J Oral Sci 2008 (Calcium Signaling) : Effects of interleukin-1alpha on the production and release of basic fibroblast growth factor in cultured nifedipine-reactive gingival fibroblasts ... The effect of interleukin-1alpha (IL-1alpha) on the production of basic fibroblast growth factor (bFGF) in human gingival fibroblasts originated from a nifedipine-reactive patient was investigated ... IL-1alpha and thapsigargin yielded significantly higher bFGF production, and also enhanced bFGF mRNA expression ... Thus, IL-1alpha increases bFGF production in nifedipine-reactive gingival fibroblasts and also influences the release of bFGF in the IL-1alpha pretreated cells
Sawaji et al., Arthritis Rheum 2008 : FGF-2 did not prevent IL-1alpha suppression of proteoglycan synthesis and did not negate its ability to stimulate the production of IL-6, IL-8, and MMPs 1, 3, and 13
Gay et al., Proc Natl Acad Sci U S A 1991 : We report here that HBGF-2 gene expression in human saphenous vein smooth muscle cells is induced by interleukin (IL)-1 alpha and IL-1 beta, inflammatory cytokines produced by many cell types in response to a variety of signals
Lee et al., Exp Eye Res 2012 (Corneal Diseases...) : Endothelial mesenchymal transformation mediated by IL-1ß induced FGF-2 in corneal endothelial cells ... Interleukin-1ß (IL-1ß) greatly upregulates FGF-2 production in CECs, thus leading to FGF-2 mediated EMT ; the whole spectrum of the injury mediated inflammation ( IL-1ß pathway ) and the subsequent EMT process ( FGF-2 pathway ) will be briefly discussed
Lee et al., Invest Ophthalmol Vis Sci 2012 : The induction of FGF-2 by IL-1ß was completely blocked by inhibitors to NF-?B activation ( sulfasalazine ) or PI 3-kinase ( LY294002 ), and both inhibitors greatly blocked cell proliferation of CECs
Schulz et al., J Neurosci 2012 : Furthermore, astrocytes in culture express high levels of FGF-2 in response to IL-1ß , and IGF-1 in response to TNF-a stimulation
Yan et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Mechanistically, LfcinB attenuated the effects of IL-1ß and FGF-2 on the expression of cartilage degrading enzymes ( MMP-1, MMP-3, and MMP-13 ), destructive cytokines ( IL-1ß and IL-6 ), and inflammatory mediators ( iNOS and TLR2 )
Finetti et al., PloS one 2012 (Carcinoma, Squamous Cell...) : AF3485 abolished IL-1ß induced activation of the EGFR, decreasing VEGF and FGF-2 expression, and tumor mediated endothelial tube formation
Lee et al., Biol Cell 2013 : Stimulation of human CEC with IL-1ß activated expression of fibroblast growth factor 2 (FGF2) and resulted in enhanced cell migration
Iwamoto et al., Immunol Lett 1989 : Furthermore, interleukin 1 (IL-1) suppressed by 50-60 % the incorporation of [ 3H ] thymidine into DNA in high density chondrocyte cultures on plastic dishes in the presence of 10 % serum or fibroblast growth factor , although it increased twofold this incorporation in 0.3 % serum alone
Nishi et al., Br J Ophthalmol 1995 (Cataract) : IL-1 and TGF-beta increased but b-FGF did not affect the PGE2 synthesis by LECs in culture
Louie et al., J Acquir Immune Defic Syndr Hum Retrovirol 1995 (Acquired Immunodeficiency Syndrome...) : As expected, IL-1ra also blocks IL-1 mediated upregulation of IL-6 and bFGF , both of which are autocrine growth factors for KS
Chandrasekhar et al., Agents Actions Suppl 1993 : With respect to neutral protease induction, FGF and PDGF potentiated IL-1 activity, TGF-beta inhibited, while EGF, IGF-1 and -2 had no effect ... With respect to IL-1 receptor expression, FGF and PDGF induced more IL-1 receptors, TGF-beta inhibited, while IGF-1, and 2 had no effect
Kobayashi et al., Immunopharmacology 1995 : Interleukin (IL)-1 alpha , platelet derived growth factor (PDGF)-BB and basic fibroblast growth factor (bFGF) increased tube formation, and their 50 % effective concentrations were 0.46, 6.4 and 140 pM, respectively
Nakamura et al., J Hypertens 1996 : bFGF , TGF-beta, interleukin-1 alpha , -1 beta and -6 stimulated DNA synthesis in VSMC significantly, whereas HGF did not
Faris et al., AIDS 1998 (Acquired Immunodeficiency Syndrome...) : OSM, IL-1 and TNF-alpha induced the transcriptional activation of a bFGF promoter reporter gene in parallel with the activation of an AP-1 reporter
Imokawa et al., Biochem J 1998 : HGF and SCF, but not bFGF , were markedly increased in culture medium in the presence of IL-1alpha , and this stimulatory effect was confined to young human fibroblasts
Sasaki et al., J Biochem 1998 : To clarify the mechanism of the IL-1 induced bFGF release, we investigated the production and gene expression of bFGF, matrix metalloproteinases ( MMPs ), syndecan 3, and inducible NO synthase (iNOS) by IL-1 treated rabbit articular chondrocytes ... IL-1 stimulated not only the release of bFGF but also the production of it ... An MMP inhibitor partially suppressed the release of bFGF, indicating that matrix degradation is at least partially involved in the IL-1 stimulated bFGF release even if increased production of bFGF is related to the release ... IL-1 sequentially stimulated mRNA expression of iNOS, membrane type 1-MMP, MMP-9 and -3, and bFGF , in that order