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CXCL10 — IL12B

Text-mined interactions from Literome

Lee et al., J Interferon Cytokine Res 2000 (Breast Neoplasms) : We found that IFN-gamma alone was a weak inducer of IP-10 in these cells, whereas IL-12 was a significantly stronger inducer of IP-10 ... In the presence of IL-12 , the tumor peptide E75 ( HER-2, 369-377 ) was a stronger inducer of IP-10 than was IL-12 alone
Li et al., Mol Ther 2004 : Further functional analysis of Stat1 indicates that a lack of Stat1 expression inhibits the Il-12 mediated induction of IP10 , a known antiangiogenic gene
Torvinen et al., Respir Res 2007 : Furthermore, inhibition studies supported the suggestion that different intracellular pathways are responsible of IFN-gamma and IL-12 mediated IP-10 secretion
Vasquez et al., Infect Immun 2008 (Leishmaniasis) : We found that CXCL10 induced IL-12 p40 production but reduced IL-10 production in uninfected DCs
Kishida et al., Clin Dev Immunol 2012 (Hepatitis C, Chronic) : IL-15 was increased at the end of induction therapy in both early virologic responders ( EAVRs ) and late virologic responders ( LAVRs ) ; CXCL-8, CXCL-10 , and CCL-4 levels were significantly decreased ( P < 0.05 ) in EAVR but not in LAVR during NCT, and IL-12 increased significantly ( P < 0.05 ) and CXCL-8 decreased significantly ( P < 0.05 ) after the end of NCT in EAVR but not in LAVR
Wei et al., J Immunol 2013 (Melanoma, Experimental) : DC-derived IL-27 is required for shaping tumor microenvironment by inducing CXCL-10 expression in myeloid derived suppressor cells and regulating IL-12 production from DCs, which lead to the recruitment and activation of NK and NKT cells resulting in immunological control of tumors
Sgadari et al., Blood 1996 : Because the human interferon-inducible protein 10 (IP-10) can also inhibit neovascularization, we tested whether IP-10 , induced by IL-12 through the intermediate IFN-gamma, might be a mediator of IL-12 angiogenesis inhibition ... Murine IL-12 induced murine IP-10 expression in mouse splenocytes, and human IFN-gamma induced human IP-10 expression in purified human endothelial cells, suggesting that IL-12 can induce IP-10 expression in certain cells
Angiolillo et al., Ann N Y Acad Sci 1996 (Burkitt Lymphoma...) : IL-12 is an inducer of IFN-gamma and indirectly of IP-10 , an IFN-gamma-inducible protein, raising the possibility that the antiangiogenic effect of IL-12 is mediated by IP-10
Coughlin et al., Immunity 1998 (Mammary Neoplasms, Experimental...) : IL-12 induced angiogenesis inhibitory activity in the responsive cells, which may be attributable to production of the chemokine IP-10