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AKT2 — PRKDC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dragoi et al., EMBO J 2005
:
DNA-PKcs , but not TLR9, is
required for activation of
Akt by CpG-DNA ... Further in vitro analysis using purified DNA-PK and recombinant Akt proteins reveals that
DNA-PK directly
induces phosphorylation and activation of
Akt
Boehme et al., Proc Natl Acad Sci U S A 2008
:
Correspondingly, down-regulation of
DNA-PK prevented phosphorylation of
Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53
Kim et al., Biochem Pharmacol 2009
:
We revealed that siRNA mediated suppression of
DNA-PKcs led to decreased phosphorylation of
Akt and Bad, a target molecule of Akt, and increased expression of DR4/DR5
Mannell et al., Cell Signal 2010
:
The
DNA dependent protein kinase (DNA-PK) , long known for its importance in repairing DNA double strand breaks, belongs to the phosphatidylinositol-3 kinase (PI3-K) super family and has recently been identified as one of the enzymes phosphorylating and
activating Akt
Rajagopalan et al., Science signaling 2010
(Inflammation) :
CD158d associated with the catalytic subunit of DNA dependent protein kinase ( DNA-PKcs ), promoted the recruitment of Akt to endosomes, and stimulated the
DNA-PKcs dependent phosphorylation of
Akt
Urano-Tashiro et al., J Neurosci Res 2010
:
Implication of
Akt dependent Prp19
alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation ... Here, we demonstrated that PRP19
alpha/14-3-3beta/CDC5L complex formation is
regulated by
Akt during nerve growth factor (NGF) induced neuronal differentiation of PC12 cells
Zhang et al., Blood 2011
:
Moreover, increased
AKT ( Ser473 ) phosphorylation was observed in activated B cells, reminiscent of cancers treated with rapamycin, and was
reduced by a
DNA-pk inhibitor
Minjgee et al., Int J Radiat Oncol Biol Phys 2011
:
K-RAS ( V12 ) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR dependent
Akt signaling and
activation of
DNA-PKcs
Stronach et al., Neoplasia (New York, N.Y.) 2011
(Carcinoma...) :
DNA-PK mediates
AKT activation and apoptosis inhibition in clinically acquired platinum resistance ... Insulin mediated activation of AKT is unaffected by DNA-PK inhibitor treatment, suggesting that this effect is restricted to DNA damage mediated activation of AKT and that, clinically,
DNA-PK inhibition might
prevent platinum induced
AKT activation without interfering with normal glucose homeostasis, an unwanted toxicity of direct AKT inhibitors
Furusawa et al., Cancer Lett 2012
(Leukemia) :
Inhibition of ataxia-telangiectasia mutated (ATM) or DNA-PK revealed that
DNA-PK , rather than ATM, was preferentially
involved in
Akt phosphorylation and cell survival after US-exposure in all cell lines
Toulany et al., Mol Cancer Res 2012
:
The data showed indicate for the first time that
Akt through an immediate complex formation with DNA-PKcs can
stimulate the accumulation of
DNA-PKcs at DNA-DSBs and promote DNA-PKcs activity for efficient NHEJ DNA-DSB repair
Li et al., J Biol Chem 2013
:
Chemical inhibition of
DNA-PK , knockdown or deficiency of DNA-PK catalytic subunit (DNA-PKcs), or knock-out of the DNA-PK component Ku86
inhibited rapamycin induced
Akt phosphorylation ... Accordingly, simultaneous inhibition of mTOR and
DNA-PK did not
stimulate Akt activity and synergistically inhibited the growth of cancer cells both in vitro and in vivo