Gene interactions and pathways from curated databases and text-mining

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MAPK8 — TAT

Text-mined interactions from Literome

Mischiati et al., AIDS 1999 (MAP Kinase Signaling System) : Moreover, both GST-Tat2E and GST-Tat1E also stimulated ERK/MAPK
Bruce-Keller et al., J Neurochem 2001 : Lastly, pre-treatment of microglial cells with physiological concentrations of 17 beta-estradiol suppressed Tat mediated microglial activation by interfering with Tat induced MAPK activation
Sui et al., J Immunol 2006 : Thus, the inhibition of p38 MAPK and JNK protected neurons from Tat induced apoptosis, whereas the inhibition of p38 MAPK , but not of JNK, was sufficient to prevent Tat- and gp120 mediated activation of monocytes
Gee et al., J Immunol 2007 : IL-10 regulation by HIV-Tat in primary human monocytic cells : involvement of calmodulin/calmodulin dependent protein kinase activated p38 MAPK and Sp-1 and CREB-1 transcription factors
Bai et al., BMC infectious diseases 2008 : The effects of HIV-1 Tat on barrier function of the RPE may be mediated by ERK MAPK and NF-kappaB activation, which may represent potential targets for novel therapeutic approaches for the retinopathy induced by HIV infection
Chen et al., Neoplasia (New York, N.Y.) 2009 (Cell Transformation, Neoplastic...) : By using colony formation in soft agar, ( 3 ) H-TdR incorporation, cell cycle, and microarray gene expression analyses, we demonstrated that Tat enhanced proliferation as well as mitogen activated protein kinase , signal transducer and activator of transcription 3, and phosphatidylinositol 3-kinase/protein kinase B signaling induced by Kaposin A in NIH3T3 cells
Fu et al., Journal of neuroinflammation 2011 (HIV Infections...) : HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen activated protein kinase dependent manner
Kim et al., Immune network 2011 : TAT-CD137Lct increased phosphorylation of Erk, p38 MAPK and Jnk, and activated transcription factors C/EBP and CREB
Gibellini et al., J Immunol 1998 : Furthermore, extracellular Tat induced a rapid ( peak at 5-15 min ) stimulation of the MAPK catalytic activity in primary PBMC