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INS — PAK1

Text-mined interactions from Literome

Lessmann et al., Exp Hematol 2006 : Ins/IGF-1 , like antigen ( Ag ), also stimulates the Rac dependent activation of PAK as well as the production of hydrogen peroxide ( H2O2 )
Lim et al., Endocrinology 2009 : After insulin treatment, Cdc42 dependent p21 activated kinase-1 (PAK1) activation was also detected, and transfection of small interfering RNA against Cdc42 or of dominant negative Cdc42 ( T17N ) impaired insulin stimulated PAK1 activation, actin remodeling, and GLP-1 secretion ... Knockdown or inhibition of Cdc42 and PAK1 activities also prevented activation of MAPK/ERK (MEK)-1/2-ERK1/2 by insulin , which was previously identified as a critical pathway for insulin regulated GLP-1 release ... Taken together, these data identify a novel signaling pathway in the endocrine L cell, whereby Cdc42 regulates actin remodeling, activation of the cannonical 1/2-ERK1/2 pathway and PAK1 , and GLP-1 secretion in response to insulin
Chiang et al., Endocrinology 2013 : Insulin stimulated Pak1 activation through increasing its Thr423 phosphorylation in gut gcg expressing cell lines, associated with increased gcg mRNA levels
Sylow et al., Diabetes 2013 : Rac1 protein expression and insulin stimulated PAK ( Thr423 ) phosphorylation were decreased in muscles of high fat fed mice