◀ Back to TP53

TP53 — UCN

Text-mined interactions from Literome

Yu et al., Cancer Res 2002 (Colonic Neoplasms) : UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation induced G ( 2 ) -M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1 ... Here we show that UCN-01 prevented IR-induced p53 up-regulation and p53 phosphorylation on serine 20, a site previously identified for Chk2 ( or/and Chk1 ) kinase
Wu et al., BMC cancer 2013 (Carcinoma, Hepatocellular...) : UCN-01 induces S and G2/M cell cycle arrest through the p53/p21 ( waf1 ) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines