◀ Back to IRS1
IRS1 — JAK1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
IRS1
→
JAK1
(directlyIncreases, IRS1 Activity)
Cengel et al., J Biol Chem 1999*
Evidence: Phosphorylation of IRS-1 by JAK1 leads to generation of interaction sites for SH2 domain containing proteins.
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BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
IRS-1 (IRS1)
(modification, activates)
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NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IRS1 (IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database IL4-mediated signaling events:
IRS1 (IRS1)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IRS1-2 (IRS2/IRS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IRS1-2 (IRS2/IRS1)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1)
(modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: assay, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Cengel et al., J Biol Chem 1999
:
JAK1 dependent phosphorylation of
insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation
Hartman et al., Biochem Biophys Res Commun 2001
:
Importantly, only FRAP dependent IRS-1 ( 511-772 ) serine phosphorylation inhibited by 50 % subsequent
JAK1 dependent tyrosine phosphorylation of
IRS-1 ... Taken together, these data indicate that FRAP, but not p70 ( s6k ), is a likely physiologic IRS-1 serine kinase that negatively regulates
JAK1 dependent
IRS-1 tyrosine phosphorylation and suggests that FRAP may modulate IRS dependent cytokine signaling
Burfoot et al., J Biol Chem 1997
:
Janus kinase dependent
activation of
insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons ... For the mutant human fibrosarcoma cell lines, phosphorylation of
IRS-1 through the insulin-like growth factor receptor is
independent of
JAK1 , JAK2, or Tyk2 ... For the alphabeta-IFNs, activation of
IRS-1 is
dependent on
JAK1 and Tyk2, consistent with the interdependence of these kinases in the IFN-alphabeta response ... For IL-4 and OSM phosphorylation of
IRS-1 in the human fibrosarcoma cells is largely
dependent on
JAK1 but can also be mediated through Tyk2 or JAK2