Gene interactions and pathways from curated databases and text-mining

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IRS1 — JAK1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Cengel et al., J Biol Chem 1999 : JAK1 dependent phosphorylation of insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation
Hartman et al., Biochem Biophys Res Commun 2001 : Importantly, only FRAP dependent IRS-1 ( 511-772 ) serine phosphorylation inhibited by 50 % subsequent JAK1 dependent tyrosine phosphorylation of IRS-1 ... Taken together, these data indicate that FRAP, but not p70 ( s6k ), is a likely physiologic IRS-1 serine kinase that negatively regulates JAK1 dependent IRS-1 tyrosine phosphorylation and suggests that FRAP may modulate IRS dependent cytokine signaling
Burfoot et al., J Biol Chem 1997 : Janus kinase dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons ... For the mutant human fibrosarcoma cell lines, phosphorylation of IRS-1 through the insulin-like growth factor receptor is independent of JAK1 , JAK2, or Tyk2 ... For the alphabeta-IFNs, activation of IRS-1 is dependent on JAK1 and Tyk2, consistent with the interdependence of these kinases in the IFN-alphabeta response ... For IL-4 and OSM phosphorylation of IRS-1 in the human fibrosarcoma cells is largely dependent on JAK1 but can also be mediated through Tyk2 or JAK2